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Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size : The Hokkaido study

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Title: Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size : The Hokkaido study
Authors: Kobayashi, Sumitaka Browse this author →KAKEN DB
Sata, Fumihiro Browse this author
Miyashita, Chihiro Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Ban, Susumu Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Kajiwara, Jumboku Browse this author
Todaka, Takashi Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Dioxins
Birth size
Issue Date: Jan-2017
Publisher: Elsevier
Journal Title: Reproductive toxicology
Volume: 67
Start Page: 111
End Page: 116
Publisher DOI: 10.1016/j.reprotox.2016.12.002
PMID: 27939992
Abstract: Objectives: We investigated the effects of maternal polymorphisms in 3 genes encoding dioxin metabolizing enzymes in relation to prenatal dioxin levels on infant birth size in Japan. Methods: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G >A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu I (GSTM1; Non-null/null) in 421 participants using multiple linear regression models. Results: In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345g (95% confidence interval: -584, -105). Conclusions: We observed adverse effects of maternal GSTM1 null genotype on birth weight in the presence of dioxins exposure during pregnancy.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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