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Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size : The Hokkaido study
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Title: | Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size : The Hokkaido study |
Authors: | Kobayashi, Sumitaka Browse this author →KAKEN DB | Sata, Fumihiro Browse this author | Miyashita, Chihiro Browse this author →KAKEN DB | Sasaki, Seiko Browse this author →KAKEN DB | Ban, Susumu Browse this author →KAKEN DB | Araki, Atsuko Browse this author →KAKEN DB | Goudarzi, Houman Browse this author →KAKEN DB | Kajiwara, Jumboku Browse this author | Todaka, Takashi Browse this author | Kishi, Reiko Browse this author →KAKEN DB |
Keywords: | Dioxins | Pregnancy | Polymorphisms | Infants | Birth size |
Issue Date: | Jan-2017 |
Publisher: | Elsevier |
Journal Title: | Reproductive toxicology |
Volume: | 67 |
Start Page: | 111 |
End Page: | 116 |
Publisher DOI: | 10.1016/j.reprotox.2016.12.002 |
PMID: | 27939992 |
Abstract: | Objectives: We investigated the effects of maternal polymorphisms in 3 genes encoding dioxin metabolizing enzymes in relation to prenatal dioxin levels on infant birth size in Japan. Methods: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G >A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu I (GSTM1; Non-null/null) in 421 participants using multiple linear regression models. Results: In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345g (95% confidence interval: -584, -105). Conclusions: We observed adverse effects of maternal GSTM1 null genotype on birth weight in the presence of dioxins exposure during pregnancy. |
Rights: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/68032 |
Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岸 玲子
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