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Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/68057

Title: Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds
Authors: Murakami, Shusuke Browse this author
Miyaji, Hirofumi Browse this author →KAKEN DB
Nishida, Erika Browse this author
Kawamoto, Kohei Browse this author
Miyata, Saori Browse this author
Takita, Hiroko Browse this author →KAKEN DB
Akasaka, Tsukasa Browse this author →KAKEN DB
Fugetsu, Bunshi Browse this author →KAKEN DB
Iwanaga, Toshihiko Browse this author →KAKEN DB
Hongo, Hiromi Browse this author
Amizuka, Norio Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Kawanami, Masamitsu Browse this author →KAKEN DB
Keywords: Biomaterial
Cell ingrowth
Nano-dispersion
Bone tissue engineering
Issue Date: 2017
Publisher: The Japanese Society for Dental Materials and Devices
日本歯科理工学会
Journal Title: Dental Materials Journal
Volume: 36
Issue: 5
Start Page: 573
End Page: 583
Publisher DOI: 10.4012/dmj.2016-295
PMID: 28450672
Abstract: Three-dimensional collagen scaffolds coated with beta-tricalcium phosphate (β-TCP) nanoparticles reportedly exhibit good bioactivity and biodegradability. Dose effects of β-TCP nanoparticles on biocompatibility and bone forming ability were then examined. Collagen scaffold was applied with 1, 5, 10, and 25 wt% β-TCP nanoparticle dispersion and designated TCP1, TCP5, TCP10, and TCP25, respectively. Compressive strength, calcium ion release and enzyme resistance of scaffolds with β-TCP nanoparticles applied increased with β-TCP dose. TCP5 showed excellent cell-ingrowth behavior in rat subcutaneous tissue. When TCP10 was applied, osteoblastic cell proliferation and rat cranial bone augmentation were greater than for any other scaffold. The bone area of TCP10 was 7.7-fold greater than that of non-treated scaffold. In contrast, TCP25 consistently exhibited adverse biological effects. These results suggest that the application dose of β-TCP nanoparticles affects the scaffold bioproperties; consequently, the bone conductive ability of TCP10 was remarkable.
Rights: The copyright of this paper belongs to the Japanese Society for Dental Materials and Devices
Type: article
URI: http://hdl.handle.net/2115/68057
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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