| Title: | Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds |
| Authors: | Murakami, Shusuke Browse this author |
| Miyaji, Hirofumi Browse this author →KAKEN DB |
| Nishida, Erika Browse this author |
| Kawamoto, Kohei Browse this author |
| Miyata, Saori Browse this author |
| Takita, Hiroko Browse this author →KAKEN DB |
| Akasaka, Tsukasa Browse this author →KAKEN DB |
| Fugetsu, Bunshi Browse this author →KAKEN DB |
| Iwanaga, Toshihiko Browse this author →KAKEN DB |
| Hongo, Hiromi Browse this author |
| Amizuka, Norio Browse this author →KAKEN DB |
| Sugaya, Tsutomu Browse this author →KAKEN DB |
| Kawanami, Masamitsu Browse this author →KAKEN DB |
| Keywords: | Biomaterial |
| Cell ingrowth |
| Nano-dispersion |
| Bone tissue engineering |
| Issue Date: | 2017 |
| Publisher: | The Japanese Society for Dental Materials and Devices |
| 日本歯科理工学会 |
| Journal Title: | Dental Materials Journal |
| Volume: | 36 |
| Issue: | 5 |
| Start Page: | 573 |
| End Page: | 583 |
| Publisher DOI: | 10.4012/dmj.2016-295 |
| PMID: | 28450672 |
| Abstract: | Three-dimensional collagen scaffolds coated with beta-tricalcium phosphate (β-TCP) nanoparticles reportedly exhibit good bioactivity and biodegradability. Dose effects of β-TCP nanoparticles on biocompatibility and bone forming ability were then examined. Collagen scaffold was applied with 1, 5, 10, and 25 wt% β-TCP nanoparticle dispersion and designated TCP1, TCP5, TCP10, and TCP25, respectively. Compressive strength, calcium ion release and enzyme resistance of scaffolds with β-TCP nanoparticles applied increased with β-TCP dose. TCP5 showed excellent cell-ingrowth behavior in rat subcutaneous tissue. When TCP10 was applied, osteoblastic cell proliferation and rat cranial bone augmentation were greater than for any other scaffold. The bone area of TCP10 was 7.7-fold greater than that of non-treated scaffold. In contrast, TCP25 consistently exhibited adverse biological effects. These results suggest that the application dose of β-TCP nanoparticles affects the scaffold bioproperties; consequently, the bone conductive ability of TCP10 was remarkable. |
| Rights: | The copyright of this paper belongs to the Japanese Society for Dental Materials and Devices |
| Type: | article |
| URI: | http://hdl.handle.net/2115/68057 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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