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Satisfaction of switching to combination therapy with lixisenatide and basal insulin in patients with type 2 diabetes receiving multiple daily insulin injection therapy : A randomized controlled trial

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タイトル: Satisfaction of switching to combination therapy with lixisenatide and basal insulin in patients with type 2 diabetes receiving multiple daily insulin injection therapy : A randomized controlled trial
著者: Miya, Aika 著作を一覧する
Nakamura, Akinobu 著作を一覧する
Miyoshi, Hideaki 著作を一覧する
Cho, Kyu Yong 著作を一覧する
Nagai, So 著作を一覧する
Kurihara, Yoshio 著作を一覧する
Aoki, Shin 著作を一覧する
Taguri, Masataka 著作を一覧する
Terauchi, Yasuo 著作を一覧する
Atsumi, Tatsuya 著作を一覧する
キーワード: Lixisenatide
Treatment satisfaction
Type 2 diabetes
発行日: 2018年 1月
出版者: Wiley
誌名: Journal of Diabetes Investigation
巻: 9
号: 1
開始ページ: 119
終了ページ: 126
出版社 DOI: 10.1111/jdi.12654
抄録: Aims/Introduction: We compared the satisfaction levels of patients with type 2 diabetes undergoing combination therapy with lixisenatide (LIX) and basal insulin with that of patients undergoing multiple daily insulin injection (MDI) therapy. Materials and Methods: The study was a 12-week open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes receiving MDI for >3 months. Patients were randomly assigned to each treatment cohort: (i) a group that continued MDI (MDI group); and (ii) a group that switched from MDI to combination therapy with LIX and basal insulin (LIX group). The primary outcome was change in Diabetes Treatment Satisfaction Questionnaire scores from baseline to 12 weeks between these two groups. Key secondary outcomes were glycated hemoglobin and body weight changes. Results: A total of 31 patients were initially enrolled in the study, and 26 of them completed the study. The change in Diabetes Treatment Satisfaction Questionnaire scores in the LIX group was significantly greater compared with that in the MDI group. Mean changes in glycated hemoglobin levels were -0.05 ± 0.37% in the MDI group and 0.04 ± 0.38% in the LIX group (P = 0.36). Mean changes in body weight were +0.6 ± 1.8 kg in the MDI group and -2.5 ± 1.8 kg in the LIX group (P < 0.01). Conclusions: Switching from MDI to combination therapy with LIX and basal insulin improved satisfaction levels while maintaining glycemic control in Japanese patients with type 2 diabetes.
資料タイプ: article
URI: http://hdl.handle.net/2115/68064
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 三好 秀明

 

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