Title: | A new method to estimate pulmonary vascular resistance using diastolic pulmonary artery-right ventricular pressure gradients derived from continuous-wave Doppler velocity measurements of pulmonary regurgitation |
Authors: | Kaga, Sanae Browse this author |
Mikami, Taisei Browse this author →KAKEN DB |
Murayama, Michito Browse this author |
Okada, Kazunori Browse this author |
Masauzi, Nobuo Browse this author |
Nakabachi, Masahiro Browse this author |
Nishino, Hisao Browse this author |
Yokoyama, Shinobu Browse this author |
Nishida, Mutsumi Browse this author →KAKEN DB |
Hayashi, Taichi Browse this author |
Murai, Daisuke Browse this author |
Iwano, Hiroyuki Browse this author →KAKEN DB |
Sakakibara, Mamoru Browse this author |
Yamada, Satoshi Browse this author →KAKEN DB |
Tsutsui, Hiroyuki Browse this author →KAKEN DB |
Keywords: | Pulmonary vascular resistance |
Echocardiography |
Pulmonary regurgitation |
Left heart failure |
Issue Date: | Jan-2017 |
Publisher: | Springer |
Journal Title: | International journal of cardiovascular imaging |
Volume: | 33 |
Issue: | 1 |
Start Page: | 31 |
End Page: | 38 |
Publisher DOI: | 10.1007/s10554-016-0965-2 |
PMID: | 27576320 |
Abstract: | Pulmonary vascular resistance (PVR) is an important hemodynamic parameter in patients with heart failure, especially when the pulmonary arterial pressure is lower due to reduced stroke volume. Several echocardiographic methods to estimate PVR have been proposed, but their applications in patients with organic left-sided heart diseases have been limited. The aim of the present study was to examine the usefulness of our new method to estimate PVR (PVRPR) based on the continuous-wave Doppler velocity measurements of pulmonary regurgitation in these patients. In 43 patients who underwent right heart catheterization, PVRPR was calculated as the difference between the Doppler-derived early- and end-diastolic pulmonary artery (PA)-right ventricular (RV) pressure gradients divided by the cardiac output measured in the left ventricular outflow tract by echocardiography. The PVRPR correlated well with invasive PVR (PVRCATH) (r = 0.81, p < 0.001) without any fixed bias in Bland-Altman analysis. The conventional echocardiographic PVRs showed inadequate correlations with PVRCATH, or a obvious overestimation of PVRCATH. In the receiver operating characteristic analyses to determine the patients with abnormal elevation of PVRCATH (> 3 Wood units, WU), the area under the curve was the greatest for PVRPR (0.964) compared to the conventional PVRs (0.649-0.839). PVRPR had 83 % sensitivity and 100 % specificity at the optimal cut-off value of 3.10 WU in identifying patients with PVRCATH > 3 WU. Our simple and theoretical PVRPR is useful for the noninvasive estimation of PVR. |
Rights: | This is a post-peer-review, pre-copyedit version of an article published in International journal of cardiovascular imaging. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10554-016-0965-2 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/68252 |
Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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