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Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer

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タイトル: Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer
著者: Kano, Satoshi 著作を一覧する
Homma, Akihiro 著作を一覧する
Hatakeyama, Hiromitsu 著作を一覧する
Mizumachi, Takatsugu 著作を一覧する
Sakashita, Tomohiro 著作を一覧する
Kakizaki, Tomohiko 著作を一覧する
Fukuda, Satoshi 著作を一覧する
キーワード: neutrophil-to-lymphocyte ratio (NLR)
platelet-to-lymphocyte ratio (PLR)
lymphocyte-to-monocyte ratio (LMR)
head and neck cancer
chemoradiotherapy
発行日: 2017年 2月
出版者: Wiley
誌名: Head & neck
巻: 39
号: 2
開始ページ: 247
終了ページ: 253
出版社 DOI: 10.1002/hed.24576
抄録: Background: The purpose of this study was to analyze the relationship between pretreatment inflammatory markers and the prognosis of patients with oropharyngeal, hypopharyngeal, and laryngeal cancers. Methods: The data for 285 patients treated with curative intent by concurrent chemoradiotherapy (CRT) were obtained and their pretreatment inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were calculated. Results: Significant relationships were observed between a high NLR and oropharyngeal or hypopharyngeal cancer, T3 to T4, N2b to N3, and clinical stage III to IV, whereas significant relationships were observed between a high LMR and laryngeal cancer, T1 to T2, and clinical stage I to II. With regard to survival outcomes, a high NLR, a high PLR, and a low LMR were all significantly associated with decreases in overall survival OS) and disease-free survival (DFS). Furthermore, multivariate analysis showed that LMR was an independent prognostic factor. Conclusion: Pretreatment LMR was found to be an independent prognostic factor for patients with head and neck cancers treated by concurrent CRT.
Rights: This is the peer reviewed version of the following article: Kano, S., Homma, A., Hatakeyama, H., Mizumachi, T., Sakashita, T., Kakizaki, T. and Fukuda, S. (2017), Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. Head Neck, 39: 247–253, which has been published in final form at http://dx.doi.org/10.1002/hed.24576. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/68256
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加納 里志

 

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