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Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer
| Title: | Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer |
| Authors: | Kano, Satoshi Browse this author →KAKEN DB | | Homma, Akihiro Browse this author →KAKEN DB | | Hatakeyama, Hiromitsu Browse this author →KAKEN DB | | Mizumachi, Takatsugu Browse this author →KAKEN DB | | Sakashita, Tomohiro Browse this author →KAKEN DB | | Kakizaki, Tomohiko Browse this author | | Fukuda, Satoshi Browse this author →KAKEN DB |
| Keywords: | neutrophil-to-lymphocyte ratio (NLR) | | platelet-to-lymphocyte ratio (PLR) | | lymphocyte-to-monocyte ratio (LMR) | | head and neck cancer | | chemoradiotherapy |
| Issue Date: | Feb-2017 |
| Publisher: | Wiley |
| Journal Title: | Head & neck |
| Volume: | 39 |
| Issue: | 2 |
| Start Page: | 247 |
| End Page: | 253 |
| Publisher DOI: | 10.1002/hed.24576 |
| PMID: | 27617428 |
| Abstract: | Background: The purpose of this study was to analyze the relationship between pretreatment inflammatory markers and the prognosis of patients with oropharyngeal, hypopharyngeal, and laryngeal cancers. Methods: The data for 285 patients treated with curative intent by concurrent chemoradiotherapy (CRT) were obtained and their pretreatment inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were calculated. Results: Significant relationships were observed between a high NLR and oropharyngeal or hypopharyngeal cancer, T3 to T4, N2b to N3, and clinical stage III to IV, whereas significant relationships were observed between a high LMR and laryngeal cancer, T1 to T2, and clinical stage I to II. With regard to survival outcomes, a high NLR, a high PLR, and a low LMR were all significantly associated with decreases in overall survival OS) and disease-free survival (DFS). Furthermore, multivariate analysis showed that LMR was an independent prognostic factor. Conclusion: Pretreatment LMR was found to be an independent prognostic factor for patients with head and neck cancers treated by concurrent CRT. |
| Rights: | This is the peer reviewed version of the following article: Kano, S., Homma, A., Hatakeyama, H., Mizumachi, T., Sakashita, T., Kakizaki, T. and Fukuda, S. (2017), Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. Head Neck, 39: 247–253, which has been published in final form at http://dx.doi.org/10.1002/hed.24576. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/68256 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加納 里志
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