HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer

Files in This Item:
HeadNeck39_247.pdf427.63 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/68256

Title: Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer
Authors: Kano, Satoshi Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Mizumachi, Takatsugu Browse this author →KAKEN DB
Sakashita, Tomohiro Browse this author →KAKEN DB
Kakizaki, Tomohiko Browse this author
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: neutrophil-to-lymphocyte ratio (NLR)
platelet-to-lymphocyte ratio (PLR)
lymphocyte-to-monocyte ratio (LMR)
head and neck cancer
chemoradiotherapy
Issue Date: Feb-2017
Publisher: Wiley
Journal Title: Head & neck
Volume: 39
Issue: 2
Start Page: 247
End Page: 253
Publisher DOI: 10.1002/hed.24576
PMID: 27617428
Abstract: Background: The purpose of this study was to analyze the relationship between pretreatment inflammatory markers and the prognosis of patients with oropharyngeal, hypopharyngeal, and laryngeal cancers. Methods: The data for 285 patients treated with curative intent by concurrent chemoradiotherapy (CRT) were obtained and their pretreatment inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were calculated. Results: Significant relationships were observed between a high NLR and oropharyngeal or hypopharyngeal cancer, T3 to T4, N2b to N3, and clinical stage III to IV, whereas significant relationships were observed between a high LMR and laryngeal cancer, T1 to T2, and clinical stage I to II. With regard to survival outcomes, a high NLR, a high PLR, and a low LMR were all significantly associated with decreases in overall survival OS) and disease-free survival (DFS). Furthermore, multivariate analysis showed that LMR was an independent prognostic factor. Conclusion: Pretreatment LMR was found to be an independent prognostic factor for patients with head and neck cancers treated by concurrent CRT.
Rights: This is the peer reviewed version of the following article: Kano, S., Homma, A., Hatakeyama, H., Mizumachi, T., Sakashita, T., Kakizaki, T. and Fukuda, S. (2017), Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. Head Neck, 39: 247–253, which has been published in final form at http://dx.doi.org/10.1002/hed.24576. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/68256
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加納 里志

Export metadata:

OAI-PMH ( junii2 , jpcoar )


 

Feedback - Hokkaido University