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Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum)


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タイトル: Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum)
著者: Ogawa, Hirohito 著作を一覧する
Kajihara, Masahiro 著作を一覧する
Nao, Naganori 著作を一覧する
Shigeno, Asako 著作を一覧する
Fujikura, Daisuke 著作を一覧する
Hang'ombe, Bernard M. 著作を一覧する
Mweene, Aaron S. 著作を一覧する
Mutemwa, Alisheke 著作を一覧する
Squarre, David 著作を一覧する
Yamada, Masao 著作を一覧する
Higashi, Hideaki 著作を一覧する
Sawa, Hirofumi 著作を一覧する
Takada, Ayato 著作を一覧する
キーワード: adenovirus
Eidolon helvum
発行日: 2017年12月
出版者: MDPI
誌名: Viruses
巻: 9
号: 12
開始ページ: 371
出版社 DOI: 10.3390/v9120371
抄録: Bats are important reservoirs for emerging zoonotic viruses. For extensive surveys of potential pathogens in straw-colored fruit bats (Eidolon helvum) in Zambia, a total of 107 spleen samples of E. helvum in 2006 were inoculated onto Vero E6 cells. The cell culture inoculated with one of the samples (ZFB06-106) exhibited remarkable cytopathic changes. Based on the ultrastructural property in negative staining and cross-reactivity in immunofluorescence assays, the virus was suspected to be an adenovirus, and tentatively named E. helvum adenovirus 06-106 (EhAdV 06-106). Analysis of the full-length genome of 30,134 bp, determined by next-generation sequencing, showed the presence of 28 open reading frames. Phylogenetic analyses confirmed that EhAdV 06-106 represented a novel bat adenovirus species in the genus Mastadenovirus. The virus shared similar characteristics of low G + C contents with recently isolated members of species Bat mastadenoviruses E, F and G, from which EhAdV 06-106 diverged by more than 15% based on the distance matrix analysis of DNA polymerase amino acid sequences. According to the taxonomic criteria, we propose the tentative new species name “Bat mastadenovirus H”. Because EhAdV 06-106 exhibited a wide in vitro cell tropism, the virus might have a potential risk as an emerging virus through cross-species transmission.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 高田 礼人


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