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Enhanced radiobiological effects at the distal end of a clinical proton beam : in vitro study


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タイトル: Enhanced radiobiological effects at the distal end of a clinical proton beam : in vitro study
著者: Matsumoto, Yoshitaka 著作を一覧する
Matsuura, Taeko 著作を一覧する
Wada, Mami 著作を一覧する
Egashira, usuke 著作を一覧する
Nishio, Teiji 著作を一覧する
Furusawa, Yoshiya 著作を一覧する
キーワード: proton beam
biological effectiveness
distal end
cell survival
spread-out Bragg-peak
発行日: 2014年 7月 1日
出版者: Oxford University Press
誌名: Journal of Radiation Research
巻: 55
号: 4
開始ページ: 816
終了ページ: 822
出版社 DOI: 10.1093/jrr/rrt230
抄録: In the clinic, the relative biological effectiveness (RBE) value of 1.1 has usually been used in relation to the whole depth of the spread-out Bragg-peak (SOBP) of proton beams. The aim of this study was to confirm the actual biological effect in the SOBP at the very distal end of clinical proton beams using an in vitro cell system. A human salivary gland tumor cell line, HSG, was irradiated with clinical proton beams (accelerated by 190 MeV/u) and examined at different depths in the distal part and the center of the SOBP. Surviving fractions were analyzed with the colony formation assay. Cell survival curves and the survival parameters were obtained by fitting with the linear?quadratic (LQ) model. The RBE at each depth of the proton SOBP compared with that for X-rays was calculated by the biological equivalent dose, and the biological dose distribution was calculated from the RBE and the absorbed dose at each position. Although the physical dose distribution was flat in the SOBP, the RBE values calculated by the equivalent dose were significantly higher (up to 1.56 times) at the distal end than at the center of the SOBP. Additionally, the range of the isoeffective dose was extended beyond the range of the SOBP (up to 4.1 mm). From a clinical point of view, this may cause unexpected side effects to normal tissues at the distal position of the beam. It is important that the beam design and treatment planning take into consideration the biological dose distribution.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松浦 妙子


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