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Expression and in situ localization ofGATA4, 5and6 mRNAs in ovine conceptuses and uterine endometria during the peri-implantation period

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Title: Expression and in situ localization ofGATA4, 5and6 mRNAs in ovine conceptuses and uterine endometria during the peri-implantation period
Authors: Bai, Hanako Browse this author
Sakurai, Toshihiro Browse this author
Godkin, James D. Browse this author
Imakawa, Kazuhiko Browse this author
Keywords: GATA4-6
gene expression
ovine uterus
peri-implantation period
Issue Date: Apr-2014
Publisher: Blackwell Publishing
Journal Title: Animal Science Journal
Volume: 85
Issue: 4
Start Page: 388
End Page: 394
Publisher DOI: 10.1111/asj.12156
Abstract: Abstract: In vertebrates, six GATA transcription factors, GATA1 through GATA6, have been identified and GATA1-3 is known to be involved in hematopoietic developments, while GATA4-6 play roles in cardiac and endoderm developments. Recently, we and others have found that GATA2 and GATA3 found in the trophectoderm plays a role in gene expression specific to this cell type, but GATA4-6 have not been well characterized in early embryonic developments. Using quantitative polymerase chain reaction (qPCR) and in situ hybridization, we examined the expression of GATA4, 5 and 6 messenger RNAs (mRNAs) in ovine conceptuses and uteri during the peri-implantation period. In ovine conceptuses, GATA4, 5 and 6 transcripts were present on days 15, 17 and 21 (day 0 = day of mating), and high GATA5 and 6 mRNAs were found on day 21, most of which were localized in the trophectoderm and endoderm. Moreover, minute and substantial GATA4 and 5 mRNAs were found in days 15 and 21 uterine endometria, respectively. Increase in GATA4-6 transcripts in day 21 uteri indicates that in addition to GATA1-3, GATA4-6 may also play a potentially novel role in the development of ovine trophectoderm, endoderm and/or uterine endometria following conceptus attachment to the uterine epithelium.
Rights: © 2013 Japanese Society of Animal Science, This is the peer reviewed version of the following article: [Animal Science Journal; 85(4): pp388-394, 2014], which has been published in final form at [10.1111/asj.12156]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 唄 花子

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