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Expression and Potential Role of GATA Factors in Trophoblast Development

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Title: Expression and Potential Role of GATA Factors in Trophoblast Development
Authors: BAI, Hanako Browse this author
SAKURAI, Toshihiro Browse this author
GODKIN, James D. Browse this author
IMAKAWA, Kazuhiko Browse this author
Keywords: Development
GATA factors
Transcriptional regulation
Trophectoderm (TE)
Issue Date: 2013
Publisher: 日本繁殖生物学会
Journal Title: Journal of Reproduction and Development
Volume: 59
Issue: 1
Start Page: 1
End Page: 6
Publisher DOI: 10.1262/jrd.2012-100
Abstract: Despite exhaustive studies, molecular mechanisms governing blastocyst formation, implantation to the uterine endometrium and placentation have not been definitively characterized. GATA family proteins are a group of zinc finger transcription factors, for which gene ablations eventually result in embryonic death later in pregnancy. These findings suggested that GATA factors are not essential for early embryonic development. However, recent studies from our laboratory and others have revealed that GATA proteins are involved in the regulation of key genes expressed by the trophectoderm that underpin the transition from the morula to trophoblast, and trophectoderm maintenance. Consequently, it is important to consider the current understanding how GATA factors govern early trophectoderm development.
Rights: ©2013 by the Society for Reproduction and Development
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 唄 花子

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