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Hokkaido University Collection of Scholarly and Academic Papers >
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Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years
| Title: | Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years |
| Other Titles: | Frequency of malformed infants in a tertiary center over a period of ten years in Hokkaido, Japan | | Malformed newborns in a tertiary center |
| Authors: | Hayasaka, Itaru Browse this author | | Cho, Kazutoshi Browse this author →KAKEN DB | | Uzuki, Yutaka Browse this author | | Morioka, Keita Browse this author | | Akimoto, Takuma Browse this author | | Ishikawa, Satoshi Browse this author | | Takei, Kohta Browse this author | | Yamada, Takahiro Browse this author →KAKEN DB | | Morikawa, Mamoru Browse this author →KAKEN DB | | Yamada, Takashi Browse this author →KAKEN DB | | Ariga, Tadashi Browse this author →KAKEN DB | | Minakami, Hisanori Browse this author →KAKEN DB |
| Keywords: | congenital heart disease | | congenital malformation | | fetal echocardiography | | prenatal diagnosis | | tertiary center |
| Issue Date: | Mar-2017 |
| Publisher: | Wiley |
| Journal Title: | Journal of Obstetrics and Gynaecology Research |
| Volume: | 43 |
| Issue: | 3 |
| Start Page: | 505 |
| End Page: | 510 |
| Publisher DOI: | 10.1111/jog.13229 |
| PMID: | 27987336 |
| Abstract: | Aim: This retrospective study was performed to determine the frequency of malformed infants born at a tertiary center in Hokkaido, Japan. The accuracy of prenatal diagnosis rates was also investigated. Methods: An observational study was performed using data of 1509 and 1743 newborn infants at a single center during two study periods, 2005-2009 (first) and 2010-2014 (second), respectively. Cases including minor anomalies (accessory auricle, nevus and fistula auris congenita) were not included. Results: In total, 274 and 569 malformations were identified in 191 and 337 newborn infants in the first and second study periods, respectively. The number of malformed infants increased significantly over time (13% [191/1509] vs 19% [337/1743], respectively; P < 0.001), mainly as a result of an increase in cases of congenital heart disease (CHD), from 59 to 141 (31% [59/191] vs 42% [141/337] of all malformed infants in the first and second periods, respectively). The overall accurate prenatal diagnosis rate improved over time from 47% (128/274) to 58% (329/569) because of significant improvements in accurate prenatal diagnosis of CHD subtypes (23% [16/70] vs 65% [151/232] in the first and second periods, respectively, P < 0.0001). Conclusions: The frequency of malformed newborns was higher in the tertiary center than in the general population. The increased number of cases with prenatal suspicion and diagnosis of CHD contributed to the increased frequency of malformed infants during the study period. |
| Rights: | This is the peer reviewed version of the following article: Hayasaka, I., Cho, K., Uzuki, Y., Morioka, K., Akimoto, T., Ishikawa, S., Takei, K., Yamada, T., Morikawa, M., Yamada, T., Ariga, T., and Minakami, H. (2017) Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years. J. Obstet. Gynaecol. Res., 43: 505–510, which has been published in final form at http://dx.doi.org/10.1111/jog.13229. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/68398 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 水上 尚典
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