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Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years

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Title: Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years
Other Titles: Frequency of malformed infants in a tertiary center over a period of ten years in Hokkaido, Japan
Malformed newborns in a tertiary center
Authors: Hayasaka, Itaru Browse this author
Cho, Kazutoshi Browse this author →KAKEN DB
Uzuki, Yutaka Browse this author
Morioka, Keita Browse this author
Akimoto, Takuma Browse this author
Ishikawa, Satoshi Browse this author
Takei, Kohta Browse this author
Yamada, Takahiro Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Yamada, Takashi Browse this author →KAKEN DB
Ariga, Tadashi Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: congenital heart disease
congenital malformation
fetal echocardiography
prenatal diagnosis
tertiary center
Issue Date: Mar-2017
Publisher: Wiley
Journal Title: Journal of Obstetrics and Gynaecology Research
Volume: 43
Issue: 3
Start Page: 505
End Page: 510
Publisher DOI: 10.1111/jog.13229
PMID: 27987336
Abstract: Aim: This retrospective study was performed to determine the frequency of malformed infants born at a tertiary center in Hokkaido, Japan. The accuracy of prenatal diagnosis rates was also investigated. Methods: An observational study was performed using data of 1509 and 1743 newborn infants at a single center during two study periods, 2005-2009 (first) and 2010-2014 (second), respectively. Cases including minor anomalies (accessory auricle, nevus and fistula auris congenita) were not included. Results: In total, 274 and 569 malformations were identified in 191 and 337 newborn infants in the first and second study periods, respectively. The number of malformed infants increased significantly over time (13% [191/1509] vs 19% [337/1743], respectively; P < 0.001), mainly as a result of an increase in cases of congenital heart disease (CHD), from 59 to 141 (31% [59/191] vs 42% [141/337] of all malformed infants in the first and second periods, respectively). The overall accurate prenatal diagnosis rate improved over time from 47% (128/274) to 58% (329/569) because of significant improvements in accurate prenatal diagnosis of CHD subtypes (23% [16/70] vs 65% [151/232] in the first and second periods, respectively, P < 0.0001). Conclusions: The frequency of malformed newborns was higher in the tertiary center than in the general population. The increased number of cases with prenatal suspicion and diagnosis of CHD contributed to the increased frequency of malformed infants during the study period.
Rights: This is the peer reviewed version of the following article: Hayasaka, I., Cho, K., Uzuki, Y., Morioka, K., Akimoto, T., Ishikawa, S., Takei, K., Yamada, T., Morikawa, M., Yamada, T., Ariga, T., and Minakami, H. (2017) Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years. J. Obstet. Gynaecol. Res., 43: 505–510, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 水上 尚典

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