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Factors associated with an inadequate hypoglycemia in the insulin tolerance test in Japanese patients with suspected or proven hypopituitarism
| Title: | Factors associated with an inadequate hypoglycemia in the insulin tolerance test in Japanese patients with suspected or proven hypopituitarism |
| Authors: | Takahashi, Kiyohiko Browse this author | | Nakamura, Akinobu Browse this author →KAKEN DB | | Miyoshi, Hideaki Browse this author →KAKEN DB | | Nomoto, Hiroshi Browse this author | | Kameda, Hiraku Browse this author | | Cho, Kyu Yong Browse this author | | Nagai, So Browse this author →KAKEN DB | | Shimizu, Chikara Browse this author →KAKEN DB | | Taguri, Masataka Browse this author | | Terauchi, Yasuo Browse this author | | Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | Insulin tolerance test | | Hypopituitarism | | Insulin | | Homeostasis model assessment of insulin resistance |
| Issue Date: | Apr-2017 |
| Publisher: | The Japan Endocrine Society |
| Journal Title: | Endocrine Journal |
| Volume: | 64 |
| Issue: | 4 |
| Start Page: | 387 |
| End Page: | 392 |
| Publisher DOI: | 10.1507/endocrj.EJ16-0332 |
| PMID: | 28260701 |
| Abstract: | We attempted to identify the predictors of an inadequate hypoglycemia in insulin tolerance test (ITT), defined as a blood glucose level higher than 2.8 mmol/L after insulin injection, in Japanese patients with suspected or proven hypopituitarism. A total of 78 patients who had undergone ITT were divided into adequate and inadequate hypoglycemia groups. The relationships between the subjects' clinical parameters and inadequate hypoglycemia in ITT were analyzed. Stepwise logistic regression analysis identified high systolic blood pressure (SBP) and high homeostasis model assessment of insulin resistance (HOMA-IR) as being independent factors associated with inadequate hypoglycemia in ITT. Receiver operating characteristic (ROC) curve analysis revealed the cutoff value for inadequate hypoglycemia was 109 mmHg for SBP and 1.4 for HOMA-IR. The areas under ROC curve for SBP and HOMA-IR were 0.72 and 0.86, respectively. We confirmed that high values of SBP and HOMA-IR were associated with inadequate hypoglycemia in ITT, regardless of the degree of reduction of pituitary hormone levels. Furthermore, the strongest predictor of inadequate hypoglycemia was obtained by using the cutoff value of HOMA-IR. Our results suggest that HOMA-IR is a useful pre-screening tool for ITT in these populations. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/68405 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 三好 秀明
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