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Usefulness of the octreotide test in Japanese patients for predicting the presence/absence of somatostatin receptor 2 expression in insulinomas

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タイトル: Usefulness of the octreotide test in Japanese patients for predicting the presence/absence of somatostatin receptor 2 expression in insulinomas
著者: Nakamura, Akinobu 著作を一覧する
Mitsuhashi, Tomoko 著作を一覧する
Takano, Yoshinari 著作を一覧する
Miyoshi, Hideaki 著作を一覧する
Kameda, Hiraku 著作を一覧する
Nomoto, Hiroshi 著作を一覧する
Nagai, So 著作を一覧する
Hatanaka, Yutaka 著作を一覧する
Shimizu, Chikara 著作を一覧する
Terauchi, Yasuo 著作を一覧する
Atsumi, Tatsuya 著作を一覧する
キーワード: Insulinoma
Octreotide
Somatostatin receptor
発行日: 2016年 2月
出版者: The Japan Endocrine Society
誌名: Endocrine Journal
巻: 63
号: 2
開始ページ: 135
終了ページ: 142
出版社 DOI: 10.1507/endocrj.EJ15-0371
抄録: We investigated the relationship between the results of the octreotide test and somatostatin receptor (SSTR) 2 expression in insulinoma patients, to evaluate the usefulness of this test for predicting SSTR2 expression in insulinomas in Japanese patients. Five females and one male were included in the study. All patients underwent the octreotide test before the surgery carried out to resect the tumor, and histopathological examination of the resected tumor was performed by a single experienced pathologist. SSTR2 expression was evaluated by the SSTR2 immunohistochemistry scoring system. Insulinoma was clinically diagnosed and surgically resected in all six patients. In the octreotide test, suppression of insulin secretion was sufficient after loading in patients 1-4 and 6. In patient 5, however, the suppression of insulin secretion was insufficient, which resulted in severe hypoglycemia with endogenous relative hyperinsulinemia after the octreotide loading. The histopathological findings revealed SSTR2 expression in the insulinomas of patients 1-4 and 6, but not in the insulinoma of patient 5. In conclusion, improvement of hyperinsulinemic hypoglycemia by octreotide in Japanese insulinoma patients was associated with SSTR2 expression in the tumor. Our results suggest that the octreotide test could be useful for predicting SSTR2 expression in the tumor.
資料タイプ: article
URI: http://hdl.handle.net/2115/68409
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 三好 秀明

 

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