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Usefulness of the octreotide test in Japanese patients for predicting the presence/absence of somatostatin receptor 2 expression in insulinomas

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Title: Usefulness of the octreotide test in Japanese patients for predicting the presence/absence of somatostatin receptor 2 expression in insulinomas
Authors: Nakamura, Akinobu Browse this author
Mitsuhashi, Tomoko Browse this author
Takano, Yoshinari Browse this author
Miyoshi, Hideaki Browse this author
Kameda, Hiraku Browse this author
Nomoto, Hiroshi Browse this author
Nagai, So Browse this author
Hatanaka, Yutaka Browse this author
Shimizu, Chikara Browse this author
Terauchi, Yasuo Browse this author
Atsumi, Tatsuya Browse this author
Keywords: Insulinoma
Octreotide
Somatostatin receptor
Issue Date: Feb-2016
Publisher: The Japan Endocrine Society
Journal Title: Endocrine Journal
Volume: 63
Issue: 2
Start Page: 135
End Page: 142
Publisher DOI: 10.1507/endocrj.EJ15-0371
PMID: 26567922
Abstract: We investigated the relationship between the results of the octreotide test and somatostatin receptor (SSTR) 2 expression in insulinoma patients, to evaluate the usefulness of this test for predicting SSTR2 expression in insulinomas in Japanese patients. Five females and one male were included in the study. All patients underwent the octreotide test before the surgery carried out to resect the tumor, and histopathological examination of the resected tumor was performed by a single experienced pathologist. SSTR2 expression was evaluated by the SSTR2 immunohistochemistry scoring system. Insulinoma was clinically diagnosed and surgically resected in all six patients. In the octreotide test, suppression of insulin secretion was sufficient after loading in patients 1-4 and 6. In patient 5, however, the suppression of insulin secretion was insufficient, which resulted in severe hypoglycemia with endogenous relative hyperinsulinemia after the octreotide loading. The histopathological findings revealed SSTR2 expression in the insulinomas of patients 1-4 and 6, but not in the insulinoma of patient 5. In conclusion, improvement of hyperinsulinemic hypoglycemia by octreotide in Japanese insulinoma patients was associated with SSTR2 expression in the tumor. Our results suggest that the octreotide test could be useful for predicting SSTR2 expression in the tumor.
Type: article
URI: http://hdl.handle.net/2115/68409
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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