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Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia

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Title: Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia
Authors: Komatsu, Yumiko Browse this author
Nakamura, Akinobu Browse this author →KAKEN DB
Takihata, Masahiro Browse this author
Inoue, Yuichiro Browse this author
Yahagi, Satoko Browse this author
Tajima, Kazuki Browse this author
Tsuchiya, Hirohisa Browse this author
Takano, Tatsuro Browse this author
Yamakawa, Tadashi Browse this author
Yoshida, Masahiro Browse this author
Miyoshi, Hideaki Browse this author →KAKEN DB
Terauchi, Yasuo Browse this author
Keywords: Diazoxide
Hyperinsulinemic hypoglycemia
Fluid retention
Issue Date: Mar-2016
Publisher: The Japan Endocrine Society
Journal Title: Endocrine Journal
Volume: 63
Issue: 3
Start Page: 311
End Page: 314
Publisher DOI: 10.1507/endocrj.EJ15-0428
Abstract: Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension. Fajans reported the use of diazoxide for the treatment of insulinoma in 1979. Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports about the adverse effects of this drug in Asian patients, including Japanese patients. Herein, we report the results of our retrospective clinical record review of 6 Japanese patients (3 females and 3 males, ranging in age from 58 to 91 years) with hyperinsulinemic hypoglycemia and inoperable insulinoma treated with diazoxide. Diazoxide improved control of hypoglycemic symptoms and maintained normoglycemia in 5 of the 6 patients, and was ineffective in one patient. Surprisingly, although all 6 patients received diazoxide according to the treatment strategy recommended in Western patients, 5 of the 6 patients developed edema and two developed congestive heart failure. Thus, when starting treatment with diazoxide in Japanese patients, the symptoms and signs of fluid retention should be evaluated carefully. Also, appropriate protocols for treatment with diazoxide should be evaluated by means of clinical trials in Japanese patients with hyperinsulinemic hypoglycemia.
Type: article
URI: http://hdl.handle.net/2115/68410
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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