Title: | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia |
Authors: | Komatsu, Yumiko Browse this author |
Nakamura, Akinobu Browse this author →KAKEN DB |
Takihata, Masahiro Browse this author |
Inoue, Yuichiro Browse this author |
Yahagi, Satoko Browse this author |
Tajima, Kazuki Browse this author |
Tsuchiya, Hirohisa Browse this author |
Takano, Tatsuro Browse this author |
Yamakawa, Tadashi Browse this author |
Yoshida, Masahiro Browse this author |
Miyoshi, Hideaki Browse this author →KAKEN DB |
Terauchi, Yasuo Browse this author |
Keywords: | Diazoxide |
Hyperinsulinemic hypoglycemia |
Fluid retention |
Issue Date: | Mar-2016 |
Publisher: | The Japan Endocrine Society |
Journal Title: | Endocrine Journal |
Volume: | 63 |
Issue: | 3 |
Start Page: | 311 |
End Page: | 314 |
Publisher DOI: | 10.1507/endocrj.EJ15-0428 |
Abstract: | Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension. Fajans reported the use of diazoxide for the treatment of insulinoma in 1979. Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports about the adverse effects of this drug in Asian patients, including Japanese patients. Herein, we report the results of our retrospective clinical record review of 6 Japanese patients (3 females and 3 males, ranging in age from 58 to 91 years) with hyperinsulinemic hypoglycemia and inoperable insulinoma treated with diazoxide. Diazoxide improved control of hypoglycemic symptoms and maintained normoglycemia in 5 of the 6 patients, and was ineffective in one patient. Surprisingly, although all 6 patients received diazoxide according to the treatment strategy recommended in Western patients, 5 of the 6 patients developed edema and two developed congestive heart failure. Thus, when starting treatment with diazoxide in Japanese patients, the symptoms and signs of fluid retention should be evaluated carefully. Also, appropriate protocols for treatment with diazoxide should be evaluated by means of clinical trials in Japanese patients with hyperinsulinemic hypoglycemia. |
Type: | article |
URI: | http://hdl.handle.net/2115/68410 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|