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Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia

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タイトル: Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia
著者: Komatsu, Yumiko 著作を一覧する
Nakamura, Akinobu 著作を一覧する
Takihata, Masahiro 著作を一覧する
Inoue, Yuichiro 著作を一覧する
Yahagi, Satoko 著作を一覧する
Tajima, Kazuki 著作を一覧する
Tsuchiya, Hirohisa 著作を一覧する
Takano, Tatsuro 著作を一覧する
Yamakawa, Tadashi 著作を一覧する
Yoshida, Masahiro 著作を一覧する
Miyoshi, Hideaki 著作を一覧する
Terauchi, Yasuo 著作を一覧する
キーワード: Diazoxide
Hyperinsulinemic hypoglycemia
Fluid retention
発行日: 2016年 3月
出版者: The Japan Endocrine Society
誌名: Endocrine Journal
巻: 63
号: 3
開始ページ: 311
終了ページ: 314
出版社 DOI: 10.1507/endocrj.EJ15-0428
抄録: Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension. Fajans reported the use of diazoxide for the treatment of insulinoma in 1979. Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports about the adverse effects of this drug in Asian patients, including Japanese patients. Herein, we report the results of our retrospective clinical record review of 6 Japanese patients (3 females and 3 males, ranging in age from 58 to 91 years) with hyperinsulinemic hypoglycemia and inoperable insulinoma treated with diazoxide. Diazoxide improved control of hypoglycemic symptoms and maintained normoglycemia in 5 of the 6 patients, and was ineffective in one patient. Surprisingly, although all 6 patients received diazoxide according to the treatment strategy recommended in Western patients, 5 of the 6 patients developed edema and two developed congestive heart failure. Thus, when starting treatment with diazoxide in Japanese patients, the symptoms and signs of fluid retention should be evaluated carefully. Also, appropriate protocols for treatment with diazoxide should be evaluated by means of clinical trials in Japanese patients with hyperinsulinemic hypoglycemia.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 三好 秀明


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