|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Satisfaction and efficacy of switching from daily dipeptidyl peptidase-4 inhibitors to weekly trelagliptin in patients with type 2 diabetes : Randomized controlled study
| Title: | Satisfaction and efficacy of switching from daily dipeptidyl peptidase-4 inhibitors to weekly trelagliptin in patients with type 2 diabetes : Randomized controlled study |
| Authors: | Oita, Mayuko Browse this author | | Miyoshi, Hideaki Browse this author →KAKEN DB | | Ono, Kota Browse this author | | Nakamura, Akinobu Browse this author →KAKEN DB | | Cho, Kyu Yong Browse this author | | Nomoto, Hiroshi Browse this author | | Yamamoto, Kohei Browse this author | | Omori, Kazuno Browse this author | | Manda, Naoki Browse this author | | Kurihara, Yoshio Browse this author | | Aoki, Shin Browse this author | | Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | Satisfaction | | Quality of life | | Trelagliptin | | Type 2 diabetes |
| Issue Date: | Feb-2018 |
| Publisher: | The Japan Endocrine Society |
| Journal Title: | Endocrine Journal |
| Volume: | 65 |
| Issue: | 2 |
| Start Page: | 141 |
| End Page: | 150 |
| Publisher DOI: | 10.1507/endocrj.EJ17-0303 |
| PMID: | 29093280 |
| Abstract: | We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4 inhibitors for more than 3 months. Patients were randomly assigned to a treatment cohort: (1) a group that continued taking daily DPP-4 inhibitors (daily group); or (2) a group that switched from daily DPP-4 inhibitors to a weekly DPP-4 inhibitor, trelagliptin (weekly group). The primary outcome was the change in treatment satisfaction levels from baseline to 12 weeks between the two groups, according to Diabetes Treatment Satisfaction Questionnaire (DTSQ) and Diabetes Therapy-Related Quality of Life (DTR-QOL) questionnaire scores. The changes in glycemic control and body weight were also assessed. Of 49 patients initially enrolled in the study, 47 completed the study. The change in DTSQ scores in the weekly group was not significantly different from that in the daily group. However, the improvements in total score and subscale domains 1 and 2 in the DTR-QOL analysis, which relate to burden on social/daily activities and anxiety/dissatisfaction with treatment, were significantly greater in the weekly group than the daily group (p = 0.048, 0.013 and 0.045, respectively). Mean changes in glycated hemoglobin levels and body weight were comparable between the groups. Switching from daily DPP-4 inhibitors to a weekly DPP-4 inhibitor, trelagliptin, could partially improve treatment satisfaction levels in patients with type 2 diabetes without affecting glycemic control. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/68416 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 三好 秀明
|
