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A Comparison of the effects of the GLP-1 Analogue Liraglutide and Insulin Glargine on Endothelial Function and Metabolic Parameters : A Randomized, Controlled Trial Sapporo Athero-Incretin Study 2 (SAIS2)

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/68417

Title: A Comparison of the effects of the GLP-1 Analogue Liraglutide and Insulin Glargine on Endothelial Function and Metabolic Parameters : A Randomized, Controlled Trial Sapporo Athero-Incretin Study 2 (SAIS2)
Authors: Nomoto, H. Browse this author
Miyoshi, H. Browse this author →KAKEN DB
Furumoto, T. Browse this author
Oba, K. Browse this author
Tsutsui, H. Browse this author
Miyoshi, A. Browse this author
Kondo, T. Browse this author
Tsuchida, K. Browse this author
Atsumi, T. Browse this author
Manda, N. Browse this author
Kurihara, Y. Browse this author
Aoki, S. Browse this author
SAIS Study Group Browse this author
Issue Date: Apr-2016
Publisher: World Biomedical Frontiers
Citation: World Biomedical Frontiers
Abstract: Objective: Glucagon-like peptide-1 (GLP-1) improves hyperglycemia, and it has been reported to have favorable effects on atherosclerosis. However, it has not been fully elucidated whether GLP-1 is able to improve endothelial function in patients with type 2 diabetes. Therefore, we investigated the efficacy of the GLP-1 analogue, liraglutide on endothelial function and glycemic metabolism compared with insulin glargine therapy. Materials and Methods: In this multicenter, prospective randomized parallel-group comparison study, 31 diabetic outpatients (aged 60.3 ± 10.3 years with HbA1c levels of 8.6 ± 0.8 %) with current metformin and/or sulfonylurea treatment were enrolled and randomly assigned to receive liraglutide or glargine therapy once daily for 14 weeks. Flow mediated dilatation (FMD), a comprehensive panel of hemodynamic parameters (Task Force Monitor), and serum metabolic markers were assessed before and after the treatment period. Results: A greater reduction (worsening) in %FMD was observed in the glargine group, although this change was not statistically different from the liraglutide group (liraglutide; 5.7 to 5.4 %, glargine 6.7 to 5.7 %). The augmentation index, C-peptide index, derivatives of reactive oxygen metabolites and BMI were significantly improved in the liraglutide group. Central systolic blood pressure and NT-proBNP also tended to be improved in the liraglutide-treated group, while improvements in HbA1c levels were similar between groups. Cardiac index, blood pressure and most other metabolic parameters were not different. Conclusions: Regardless of glycemic improvement, early liraglutide therapy did not affect endothelial function but may provide favorable effects on beta-cell function and cardioprotection in type 2 diabetics without advanced atherosclerosis.
Relation: http://biomedfrontiers.org/diabetes-obesity-2016-16/
Type: article
URI: http://hdl.handle.net/2115/68417
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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