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Effects of statins on thrombosis development in patients with systemic lupus erythematosus and antiphospholipid antibodies

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タイトル: Effects of statins on thrombosis development in patients with systemic lupus erythematosus and antiphospholipid antibodies
その他のタイトル: Statin effects for thrombosis in SLE with aPL
著者: Watanabe, T 著作を一覧する
Oku, K 著作を一覧する
Amengual, O 著作を一覧する
Hisada, R 著作を一覧する
Ohmura, K 著作を一覧する
Nakagawa, I 著作を一覧する
Shida, H 著作を一覧する
Bohgaki, T 著作を一覧する
Horita, T 著作を一覧する
Yasuda, S 著作を一覧する
Atsumi, T 著作を一覧する
キーワード: systemic lupus erythematosus
antiphospholipid antibodies
thrombosis
statins
発行日: 2018年 2月
出版者: SAGE Publications
誌名: Lupus
巻: 27
号: 2
開始ページ: 225
終了ページ: 234
出版社 DOI: 10.1177/0961203317716787
抄録: The objective of this study is to identify the effects of statins and risk factors for thrombosis in patients with new onset of systemic lupus erythematosus (SLE) with or without antiphospholipid antibodies (aPL). Consecutive patients with SLE without history of thrombotic events were retrospectively enrolled from April 1997 to February 2014. The development of first thrombosis and death caused by thrombosis were defined as the study endpoint. Risk and protective factors for developing thrombosis were analyzed. A total of 152 patients, 80 positive and 72 negative for aPL, were included. In aPL-positive patients, 15 developed arterial (n=6) and venous (n=9) thrombosis (median follow-up period 69 months). Cox's proportional hazards model showed that older age at SLE onset and IgG-anticardiolipin antibodies (aCL) were statistically significant risks for thrombosis. Statin therapy was identified as a statistically significant protective factor against thrombosis (hazard ratio 0.12, 95% confidence interval 0.01-0.98). In aPL-negative patients (median follow-up period 46 months), seven patients developed thrombosis (five arterial and two venous). No risk factors for thrombosis were found in this group. In aPL-positive patients with SLE, the late disease onset and the presence of IgG-aCL represented additional risk factors for thrombosis. Statin treatment appeared as a protective factor for thrombosis.
Rights: T Watanabe, K Oku, O Amengual, R Hisada, K Ohmura, I Nakagawa, H Shida, T Bohgaki, T Horita, S Yasuda, T Atsumi, Effects of statins on thrombosis development in patients with systemic lupus erythematosus and antiphospholipid antibodies, Lupus, Vol 27, Issue 2, 225-234. Copyright © 2018 The Author(s). Reprinted by permission of SAGE Publications.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/68460
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 渥美 達也

 

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