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Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin

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Title: Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin
Authors: Tateyama, Akito Browse this author
Kato, Akihito Browse this author →KAKEN DB
Miyaji, Hirofumi Browse this author →KAKEN DB
Nishida, Erika Browse this author
Iwasaki, Yasuhiro Browse this author
Fujii, Syuji Browse this author
Kawamoto, Kohei Browse this author
Shitomi, Kanako Browse this author
Furihata, Tomokazu Browse this author
Mayumi, Kayoko Browse this author
Sugaya, Tsutomu Browse this author →KAKEN DB
Keywords: α-tricalcium phosphate (TCP)
bone tissue engineering
bone paste
water-oil emulsion
Issue Date: 30-Dec-2017
Publisher: ナノ・バイオメディカル学会
Nano Biomedical Society
Journal Title: Nano Biomedicine
Volume: 9
Issue: 2
Start Page: 69
End Page: 76
Publisher DOI: 10.11344/nano.9.69
Abstract: To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects. Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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