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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
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Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin
| Title: | Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin |
| Authors: | Tateyama, Akito Browse this author | | Kato, Akihito Browse this author →KAKEN DB | | Miyaji, Hirofumi Browse this author →KAKEN DB | | Nishida, Erika Browse this author | | Iwasaki, Yasuhiro Browse this author | | Fujii, Syuji Browse this author | | Kawamoto, Kohei Browse this author | | Shitomi, Kanako Browse this author | | Furihata, Tomokazu Browse this author | | Mayumi, Kayoko Browse this author | | Sugaya, Tsutomu Browse this author →KAKEN DB |
| Keywords: | α-tricalcium phosphate (TCP) | | bone tissue engineering | | bone paste | | water-oil emulsion | | simvastatin |
| Issue Date: | 30-Dec-2017 |
| Publisher: | ナノ・バイオメディカル学会 | | Nano Biomedical Society |
| Journal Title: | Nano Biomedicine |
| Volume: | 9 |
| Issue: | 2 |
| Start Page: | 69 |
| End Page: | 76 |
| Publisher DOI: | 10.11344/nano.9.69 |
| Abstract: | To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects. Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/68466 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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