| Title: | Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients |
| Authors: | Chagan-Yasutan, Haorile Browse this author |
| Chen, Yue Browse this author |
| Lacuesta, Talitha Lea Browse this author |
| Leano, Prisca Susan A. Browse this author |
| Iwasaki, Hiroko Browse this author |
| Hanan, Firmanto Browse this author |
| Taurustiati, Delsi Browse this author |
| Ohmoto, Yasukazu Browse this author |
| Ashino, Yugo Browse this author |
| Saitoh, Hiroki Browse this author |
| Kiyomoto, Hideyasu Browse this author |
| Suzuki, Yasuhiko Browse this author →KAKEN DB |
| Telan, Freda O. Elizabeth Browse this author |
| Hattori, Toshio Browse this author |
| Keywords: | leptospirosis |
| defensin α1 |
| neutrophil gelatinase-associated lipocalin (NGAL) |
| kidney injury |
| N-acetyl-β -D-glucosidase (NAG) |
| Issue Date: | 27-Sep-2016 |
| Publisher: | MDPI |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 17 |
| Issue: | 10 |
| Start Page: | 1637 |
| Publisher DOI: | 10.3390/ijms17101637 |
| Abstract: | Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin 1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) and N-acetyl- -D-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr were r = 0.3 (p < 0.01), r = 0.29 (p < 0.01), and r = 0.02 (p = 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels (r = 0.49, p < 0.01) and uNAG/Cr levels (r = 0.47, p < 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/68482 |
| Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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