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Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients

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Title: Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients
Authors: Chagan-Yasutan, Haorile Browse this author
Chen, Yue Browse this author
Lacuesta, Talitha Lea Browse this author
Leano, Prisca Susan A. Browse this author
Iwasaki, Hiroko Browse this author
Hanan, Firmanto Browse this author
Taurustiati, Delsi Browse this author
Ohmoto, Yasukazu Browse this author
Ashino, Yugo Browse this author
Saitoh, Hiroki Browse this author
Kiyomoto, Hideyasu Browse this author
Suzuki, Yasuhiko Browse this author →KAKEN DB
Telan, Freda O. Elizabeth Browse this author
Hattori, Toshio Browse this author
Keywords: leptospirosis
defensin α1
neutrophil gelatinase-associated lipocalin (NGAL)
kidney injury
N-acetyl-β -D-glucosidase (NAG)
Issue Date: 27-Sep-2016
Publisher: MDPI
Journal Title: International Journal of Molecular Sciences
Volume: 17
Issue: 10
Start Page: 1637
Publisher DOI: 10.3390/ijms17101637
Abstract: Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin 1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) and N-acetyl- -D-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr were r = 0.3 (p < 0.01), r = 0.29 (p < 0.01), and r = 0.02 (p = 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels (r = 0.49, p < 0.01) and uNAG/Cr levels (r = 0.47, p < 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 定彦

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