| Title: | High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers |
| Authors: | Baghdadi, Muhammad Browse this author |
| Endo, Hiraku Browse this author |
| Takano, Atsushi Browse this author →KAKEN DB |
| Ishikawa, Kozo Browse this author |
| Kameda, Yosuke Browse this author |
| Wada, Haruka Browse this author →KAKEN DB |
| Miyagi, Yohei Browse this author →KAKEN DB |
| Yokose, Tomoyuki Browse this author |
| Ito, Hiroyuki Browse this author |
| Nakayama, Haruhiko Browse this author |
| Daigo, Yataro Browse this author →KAKEN DB |
| Suzuki, Nao Browse this author →KAKEN DB |
| Seino, Ken-ichiro Browse this author →KAKEN DB |
| Issue Date: | 11-Jan-2018 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 8 |
| Start Page: | 418 |
| Publisher DOI: | 10.1038/s41598-017-18796-8 |
| Abstract: | Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates the identification of novel factors that associates with disease progression and malignant degree for improving diagnostic and therapeutic strategies. Recent progress in cancer immunology research has unveiled critical roles for colony stimulating factor 1 receptor (CSF1R) in multiple aspects of the tumor microenvironment. CSF1R is expressed on tumor-associated macrophages (TAMS), and mediates important pro-tumorigenic functions. CSF1R also provides critical autocrine signals that promote cancer cell survival and proliferation. Activation of CSF1R can be achieved by two independent ligands; macrophage colony-stimulating factor (M-CSF) and interleukin 34 (IL-34). Accordingly, the expression of these ligands in cancer is expected to result in poor prognosis. In this study, we show that IL-34 and M-CSF expression correlates with poor survival in a cohort of lung cancer patients. Importantly, high co-expression of IL-34 and M-CSF associates with the poorest survival compared to cancers that show weak or absent expression of the two ligands. Furthermore, high expression of IL-34 and M-CSF associates with advanced stages of lung cancers. Together, these results indicate a correlation between IL-34/M-CSF expression with poor survival and disease progression in lung cancer patients. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/68545 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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