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Facilitation of temporal prediction by electrical stimulation to the primate cerebellar nuclei

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Title: Facilitation of temporal prediction by electrical stimulation to the primate cerebellar nuclei
Authors: Uematsu, Akiko Browse this author
Ohmae, Shogo Browse this author
Tanaka, Masaki Browse this author →KAKEN DB
Keywords: temporal processing
electrical stimulation
dentate nucleus
Issue Date: 27-Mar-2017
Publisher: Elsevier
Journal Title: Neuroscience
Volume: 346
Start Page: 190
End Page: 196
Publisher DOI: 10.1016/j.neuroscience.2017.01.023
PMID: 28131620
Abstract: The cerebellum is known to be involved in temporal information processing. However, the underlying neuronal mechanisms remain unclear. In our previous study, monkeys were trained to make a saccade in response to a single omission of periodically presented visual stimuli. To detect stimulus omission, animals had to predict the timing of each next stimulus. During this task, neurons in the cerebellar dentate nucleus exhibited a transient decrement of activity followed by a gradual increase in firing rate that peaked around the time of the next stimulus (Ohmae et al., 2013). In the present study, to address how these two components of neuronal activity contributed to omission detection, we applied electrical microstimulation to the recording site at different timing during the task. We found that electrical stimulation just before the stimulus omission shortened the latencies of both contraversive and ipsiversive saccades. Because the changes in saccade latency nonlinearly depended on the timing of stimulation in each inter-stimulus interval, and electrical stimulation just before the early stimulus in the sequence failed to evoke saccades, the neuronal activity in the dentate nucleus might regulate temporal prediction rather than facilitating saccade execution. Our results support the hypothesis that the firing modulation in each inter-stimulus interval in the dentate nucleus represents neuronal code for the temporal prediction of next stimulus.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 真樹

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