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Acinar cell response to liquid diet during rats' growth period differs in submandibular and sublingual glands from that in parotid glands

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Title: Acinar cell response to liquid diet during rats' growth period differs in submandibular and sublingual glands from that in parotid glands
Authors: Takahashi, Shigeru Browse this author →KAKEN DB
Uekita, Hiroki Browse this author
Taniwaki, Hiroto Browse this author
Domon, Takanori Browse this author →KAKEN DB
Keywords: Submandibular gland
Sublingual gland
Growth
Liquid diet
Acinar cell
Issue Date: Apr-2017
Publisher: Elsevier
Journal Title: Tissue and cell
Volume: 49
Issue: 2
Start Page: 275
End Page: 284
Publisher DOI: 10.1016/j.tice.2017.01.011
PMID: 28222888
Abstract: Continuously feeding a liquid diet to growing rodents strongly inhibits parotid gland growth, due to suppressed growth of acinar cells. This study investigated whether a liquid diet had a similar effect on submandibular and sublingual glands of growing rats. Rats were weaned on day 21 after birth and then fed a pellet diet in the control group and a liquid diet in the experimental group for 0, 1, 2, 4, and 8 weeks. Their submandibular and sublingual glands were excised, weighed, and examined histologically, immunohistochemically (using antibodies to 5'-bromo-2-deoxyuridine and cleaved caspase 3), and ultra structurally. The submandibular glands did not significantly differ between the control and experimental groups at all tested points. Only at Week 8, acinar cell area and 5'-bromo-2-deoxyuridine-labeling index of acinar cells in sublingual glands were significantly lower in the experimental group than in the control group. These results show that a liquid diet during rats' growth period had no effect on acinar cells in their submandibular glands, and only a slight effect on acinar cells in their sublingual glands of growing rats, in contrast to the marked effect of a liquid diet on parotid glands.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/68825
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 茂

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