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Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog

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Title: Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog
Authors: Kawamoto, Kohei Browse this author
Miyaji, Hirofumi Browse this author →KAKEN DB
Nishida, Erika Browse this author
Miyata, Saori Browse this author
Kato, Akihito Browse this author →KAKEN DB
Tateyama, Akito Browse this author
Furihata, Tomokazu Browse this author
Shitomi, Kanako Browse this author
Iwanaga, Toshihiko Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Keywords: artificial collagen scaffold
periodontal attachment
periodontal tissue engineering
rat cranial bone augmentation
Issue Date: 18-Apr-2018
Publisher: Dove Medical Press
Journal Title: International Journal of Nanomedicine
Volume: 13
Start Page: 2365
End Page: 2376
Publisher DOI: 10.2147/IJN.S163206
Abstract: Introduction: The 3-dimensional scaffold plays a key role in volume and quality of repair tissue in periodontal tissue engineering therapy. We fabricated a novel 3D collagen scaffold containing carbon-based 2-dimensional layered material, named graphene oxide (GO). The aim of this study was to characterize and assess GO scaffold for periodontal tissue healing of class II furcation defects in dog. Materials and methods: GO scaffolds were prepared by coating the surface of a 3D collagen sponge scaffold with GO dispersion. Scaffolds were characterized using cytotoxicity and tissue reactivity tests. In addition, GO scaffold was implanted into dog class II furcation defects and periodontal healing was investigated at 4 weeks postsurgery. Results: GO scaffold exhibited low cytotoxicity and enhanced cellular ingrowth behavior and rat bone forming ability. In addition, GO scaffold stimulated healing of dog class II furcation defects. Periodontal attachment formation, including alveolar bone, periodontal ligament-like tissue, and cementum-like tissue, was significantly increased by GO scaffold implantation, compared with untreated scaffold. Conclusion: The results suggest that GO scaffold is biocompatible and possesses excellent bone and periodontal tissue formation ability. Therefore, GO scaffold would be beneficial for periodontal tissue engineering therapy.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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