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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
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Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog
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| Title: | Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog |
| Authors: | Kawamoto, Kohei Browse this author | | Miyaji, Hirofumi Browse this author →KAKEN DB | | Nishida, Erika Browse this author | | Miyata, Saori Browse this author | | Kato, Akihito Browse this author →KAKEN DB | | Tateyama, Akito Browse this author | | Furihata, Tomokazu Browse this author | | Shitomi, Kanako Browse this author | | Iwanaga, Toshihiko Browse this author →KAKEN DB | | Sugaya, Tsutomu Browse this author →KAKEN DB |
| Keywords: | artificial collagen scaffold | | cytotoxicity | | nanocarbon | | periodontal attachment | | periodontal tissue engineering | | rat cranial bone augmentation |
| Issue Date: | 18-Apr-2018 |
| Publisher: | Dove Medical Press |
| Journal Title: | International Journal of Nanomedicine |
| Volume: | 13 |
| Start Page: | 2365 |
| End Page: | 2376 |
| Publisher DOI: | 10.2147/IJN.S163206 |
| Abstract: | Introduction: The 3-dimensional scaffold plays a key role in volume and quality of repair tissue in periodontal tissue engineering therapy. We fabricated a novel 3D collagen scaffold containing carbon-based 2-dimensional layered material, named graphene oxide (GO). The aim of this study was to characterize and assess GO scaffold for periodontal tissue healing of class II furcation defects in dog. Materials and methods: GO scaffolds were prepared by coating the surface of a 3D collagen sponge scaffold with GO dispersion. Scaffolds were characterized using cytotoxicity and tissue reactivity tests. In addition, GO scaffold was implanted into dog class II furcation defects and periodontal healing was investigated at 4 weeks postsurgery. Results: GO scaffold exhibited low cytotoxicity and enhanced cellular ingrowth behavior and rat bone forming ability. In addition, GO scaffold stimulated healing of dog class II furcation defects. Periodontal attachment formation, including alveolar bone, periodontal ligament-like tissue, and cementum-like tissue, was significantly increased by GO scaffold implantation, compared with untreated scaffold. Conclusion: The results suggest that GO scaffold is biocompatible and possesses excellent bone and periodontal tissue formation ability. Therefore, GO scaffold would be beneficial for periodontal tissue engineering therapy. |
| Rights: | http://creativecommons.org/licenses/by-nc/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/69945 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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