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Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age : The Hokkaido Study on Environment and Children's Health
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Title: | Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age : The Hokkaido Study on Environment and Children's Health |
Authors: | Minatoya, Machiko Browse this author →KAKEN DB | Itoh, Sachiko Browse this author →KAKEN DB | Araki, Atsuko Browse this author →KAKEN DB | Tamura, Naomi Browse this author →KAKEN DB | Yamazaki, Keiko Browse this author →KAKEN DB | Miyashita, Chihiro Browse this author →KAKEN DB | Kishi, Reiko Browse this author →KAKEN DB |
Keywords: | Strengths and Difficulties Questionnaire (SDQ) | adipokines | child behavioral problems | birth cohort study |
Issue Date: | Jan-2018 |
Publisher: | MDPI |
Journal Title: | International journal of environmental research and public health |
Volume: | 15 |
Issue: | 1 |
Start Page: | 120 |
Publisher DOI: | 10.3390/ijerph15010120 |
Abstract: | Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06-0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age. |
Rights: | https://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/69975 |
Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岸 玲子
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