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Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age : The Hokkaido Study on Environment and Children's Health

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/69975

Title: Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age : The Hokkaido Study on Environment and Children's Health
Authors: Minatoya, Machiko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Tamura, Naomi Browse this author →KAKEN DB
Yamazaki, Keiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Strengths and Difficulties Questionnaire (SDQ)
adipokines
child behavioral problems
birth cohort study
Issue Date: Jan-2018
Publisher: MDPI
Journal Title: International journal of environmental research and public health
Volume: 15
Issue: 1
Start Page: 120
Publisher DOI: 10.3390/ijerph15010120
Abstract: Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06-0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/69975
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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