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Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma

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Title: Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma
Authors: Kase, Satoru Browse this author →KAKEN DB
Chin, Shinki2 Browse this author →KAKEN DB
Hamanaka, Teruhiko Browse this author
Shinmei, Yasuhiro Browse this author →KAKEN DB
Ohguchi, Takeshi Browse this author
Kijima, Riki Browse this author
Matsuda, Akira Browse this author
Ishida, Susumu Browse this author →KAKEN DB
Authors(alt): Chin, Shiki2
Keywords: Atopic glaucoma
Trabeculotomy
Histopathology
Intraocular pressure
Postoperative fibrosis
Trabecular meshwork
Issue Date: 29-May-2017
Publisher: Bentham Science Publishers
Journal Title: The Open Ophthalmology Journal
Volume: 11
Start Page: 103
End Page: 106
Publisher DOI: 10.2174/1874364101711010103
Abstract: Purpose: The aim of this study was to report a case of atopic dermatitis showing elevated intraocular pressure (IOP) beyond the baseline levels followed by a modified 360-degree suture trabeculotomy, and to analyze the histological findings in the trabecular meshwork. Methods: A 40-year-old male suffered from blurred vision in the right eye (OD). He had a medical history of severe atopic dermatitis and intraocular lens implantation OU due to atopic cataract. At the initial presentation, the visual acuity was 0.03, and IOP was 35 mmHg OD. Slit-lamp examination demonstrated corneal epithelial edema OD. Increased IOP was refractory to several topical medications. The patient underwent a modified 360-degree suture trabeculotomy. The visual field defect, however, deteriorated with persistently high IOP. The patient underwent trabeculectomy together with drainage implant surgery. In the outflow routes, although there seemed to be an opening of Schlemm's canal into the anterior chamber, there was no endothelium of the canal in the region of its opening. The fibrotic changes were conspicuous around Schlemm's canal. Conclusion: The histological results indicated that trabeculotomy might not be an appropriate treatment for patients with atopic glaucoma, possibly because of excessive repair to the newly created uveoscleral outflow in addition to the increased postoperative fibrosis in the trabecular meshwork and Schlemm's canal.
Description: The author name "Shiki" is a typographical error for "Shinki".
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/69977
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 陳 進輝

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