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Blood soluble Fas levels and mortality from cardiovascular disease in middle-aged Japanese : The JACC study
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Title: | Blood soluble Fas levels and mortality from cardiovascular disease in middle-aged Japanese : The JACC study |
Authors: | Iso, Hiroyasu Browse this author →KAKEN DB | Maruyama, Koutatsu Browse this author | Eshak, Ehab S. Browse this author | Ikehara, Satoyo Browse this author | Yamagishi, Kazumasa Browse this author | Tamakoshi, Akiko Browse this author →KAKEN DB |
Keywords: | Biomarkers | Stroke | Subarachnoid hemorrhage | Coronary heart disease | Mortality | Nested-case control study |
Issue Date: | May-2017 |
Publisher: | Elsevier |
Journal Title: | Atherosclerosis |
Volume: | 260 |
Start Page: | 97 |
End Page: | 101 |
Publisher DOI: | 10.1016/j.atherosclerosis.2017.03.020 |
PMID: | 28371684 |
Abstract: | Background and aims: Limited evidence has been available on the relationship between apoptosis and cardiovascular disease in population-based samples. We examined whether blood soluble Fas (sFas) are associated with mortality from cardiovascular diseases. Methods: In a nested case-control study under a large prospective cohort, the Japan Collaborative Cohort (JACC) Study, where a total of 39,242 subjects, 40-79 years of age, provided serum samples and were followed up for 9 years, we measured sFas levels among cases and controls, matched for sex, age, area of residence and year of serum storage. Conditional logistic regression models were used to calculate odds ratio (95% CI) of mortality from stroke and stroke types, according to quartiles and 1-SD increment of sFas levels. Results: During the follow-up (1988-1997), we identified 233 (121 in men and 112 in women) deaths from total stroke, comprising 49 (18 and 31) subarachnoid hemorrhages, 55 (27 and 28) intra-parenchymal hemorrhages, 71 (44 and 27) ischemic strokes, and 97 (53 and 44) coronary heart diseases. After adjustment for cardiovascular risk factors, the multivariable odds ratio (95% CI) of subarachnoid hemorrhage associated with a 1-SD increment of sFas (1.3 ng/ml in both men and women) was 4.04 (1.07-15.3; p = 0.04). No association was found between blood sFas levels and risk of intraparenchymal hemorrhage, ischemic stroke or coronary heart disease. Conclusions: Higher blood sFas levels were associated with higher mortality from subarachnoid hemorrhage, suggesting a potential role of apoptosis factors in the development or prognosis of subarachnoid hemorrhage. |
Rights: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/70044 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉腰 暁子
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