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Evaluation of Tissue Behavior on Three-dimensional Collagen Scaffold Coated with Carbon Nanotubes and β-tricalcium Phosphate Nanoparticles

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/70067

Title: Evaluation of Tissue Behavior on Three-dimensional Collagen Scaffold Coated with Carbon Nanotubes and β-tricalcium Phosphate Nanoparticles
Authors: Miyaji, Hirofumi Browse this author →KAKEN DB
Murakami, Shusuke Browse this author
Nishida, Erika Browse this author
Akasaka, Tsukasa Browse this author →KAKEN DB
Fugetsu, Bunshi Browse this author →KAKEN DB
Umeda, Junko Browse this author
Kondoh, Katsuyoshi Browse this author
Iizuka, Tadashi Browse this author
Sugaya, Tsutomu Browse this author →KAKEN DB
Keywords: biocompatibility
nanocarbon
rat
tissue engineering
Issue Date: 1-May-2018
Publisher: 日本再生歯科医学会
Journal Title: Journal of Oral Tissue Engineering
Volume: 15
Issue: 3
Start Page: 123
End Page: 130
Publisher DOI: 10.11223/jarde.15.123
Abstract: We generated a three-dimensional collagen scaffold coated with carbon nanotubes (CNTs) and β-tricalcium phosphate (β-TCP) nanoparticles and histologically evaluated tissue behavior toward the nanomodified scaffold after subcutaneous tissue implantation in rat. Scanning electron microscopy images of the nanomodified scaffold showed that the collagen surface was enveloped by a meshwork of CNTs and dispersed β-TCP nanoparticles. Histological observations indicated that application of CNTs and β-TCP nanoparticles increased cell and blood vessel penetration into the collagen scaffold. CNTs consistently stimulated giant cell aggregation. In addition, CNTs and β-TCP application to the scaffold significantly promoted the DNA content of infiltrating cells and scaffold biodegradation compared to the untreated scaffold. The nanomodified scaffold coated with CNTs and β-TCP nanoparticles would be beneficial for tissue engineering therapy.
Rights: 日本再生歯科医学会(利用は著作権の範囲内に限られます)
Type: article
URI: http://hdl.handle.net/2115/70067
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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