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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Evaluation of Tissue Behavior on Three-dimensional Collagen Scaffold Coated with Carbon Nanotubes and β-tricalcium Phosphate Nanoparticles
| Title: | Evaluation of Tissue Behavior on Three-dimensional Collagen Scaffold Coated with Carbon Nanotubes and β-tricalcium Phosphate Nanoparticles |
| Authors: | Miyaji, Hirofumi Browse this author →KAKEN DB | | Murakami, Shusuke Browse this author | | Nishida, Erika Browse this author | | Akasaka, Tsukasa Browse this author →KAKEN DB | | Fugetsu, Bunshi Browse this author →KAKEN DB | | Umeda, Junko Browse this author | | Kondoh, Katsuyoshi Browse this author | | Iizuka, Tadashi Browse this author | | Sugaya, Tsutomu Browse this author →KAKEN DB |
| Keywords: | biocompatibility | | nanocarbon | | rat | | tissue engineering |
| Issue Date: | 1-May-2018 |
| Publisher: | 日本再生歯科医学会 |
| Journal Title: | Journal of Oral Tissue Engineering |
| Volume: | 15 |
| Issue: | 3 |
| Start Page: | 123 |
| End Page: | 130 |
| Publisher DOI: | 10.11223/jarde.15.123 |
| Abstract: | We generated a three-dimensional collagen scaffold coated with carbon nanotubes (CNTs) and β-tricalcium phosphate (β-TCP) nanoparticles and histologically evaluated tissue behavior toward the nanomodified scaffold after subcutaneous tissue implantation in rat. Scanning electron microscopy images of the nanomodified scaffold showed that the collagen surface was enveloped by a meshwork of CNTs and dispersed β-TCP nanoparticles. Histological observations indicated that application of CNTs and β-TCP nanoparticles increased cell and blood vessel penetration into the collagen scaffold. CNTs consistently stimulated giant cell aggregation. In addition, CNTs and β-TCP application to the scaffold significantly promoted the DNA content of infiltrating cells and scaffold biodegradation compared to the untreated scaffold. The nanomodified scaffold coated with CNTs and β-TCP nanoparticles would be beneficial for tissue engineering therapy. |
| Rights: | 日本再生歯科医学会(利用は著作権の範囲内に限られます) |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70067 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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