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Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice

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Title: Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice
Authors: Nakatsukasa, Akihiro Browse this author
Kuruma, Koji Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Hiono, Takahiro Browse this author
Suzuki, Mizuho Browse this author
Matsuno, Keita Browse this author →KAKEN DB
Kida, Hiroshi Browse this author →KAKEN DB
Oyamada, Takayoshi Browse this author
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: Vaccine
Influenza
Dissolving microneedle
Transdermal vaccination
Whole virus particle
Split virion
Issue Date: 15-May-2017
Publisher: Elsevier
Journal Title: Vaccine
Volume: 35
Issue: 21
Start Page: 2855
End Page: 2861
Publisher DOI: 10.1016/j.vaccine.2017.04.009
PMID: 28431812
Abstract: Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies of split virion and whole virus particle (WVP) vaccines prepared from A/Puerto Rico/8/1934 (H1N1) and A/duck/Hokkaido/Vac-3/2007 (H5N1), respectively, were evaluated. MN vaccination induced higher neutralizing antibody responses than SC vaccination in mice. Moreover, MN vaccination with a lower dose of antigens conferred protective immunity against lethal challenges of influenza viruses than SC vaccination in mice. These results suggest that the WVP vaccines administered using MN are an effective combination for influenza vaccine to be further validated in humans.Previous article in issue
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/70216
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

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