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Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system
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Title: | Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system |
Authors: | Nishioka, Kentaro Browse this author →KAKEN DB | Prayongrat, Anussara Browse this author | Ono, Kota Browse this author | Onodera, Shunsuke Browse this author | Hashimoto, Takayuki Browse this author →KAKEN DB | Katoh, Norio Browse this author →KAKEN DB | Inoue, Tetsuya Browse this author →KAKEN DB | Kinoshita, Rumiko Browse this author →KAKEN DB | Yasuda, Koichi Browse this author →KAKEN DB | Mori, Takashi Browse this author | Onimaru, Rikiya Browse this author →KAKEN DB | Shirato, Hiroki Browse this author →KAKEN DB | Shimizu, Shinichi Browse this author →KAKEN DB |
Keywords: | spot-scanning | synchrotron-based | proton beam therapy | safety | toxicity | adverse event |
Issue Date: | Mar-2018 |
Publisher: | Oxford University Press |
Journal Title: | Journal of Radiation Research |
Volume: | 59 |
Issue: | suppl_1 |
Start Page: | i63 |
End Page: | i71 |
Publisher DOI: | 10.1093/jrr/rrx083 |
Abstract: | This is a report of a single-institution prospective study evaluating the safety of a spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy (PBT) system. Data collection was performed for 56 patients with 59 treatment sites who received proton beam therapy at Hokkaido University Hospital between March 2014 and July 2015. Forty-one patients were male and 15 were female. The median age was 66 years. The primary lesion sites were prostate (n = 17), bone/soft tissue (n = 10), liver (n = 7), lung (n = 6), central nervous system (n = 5), colon (n = 2), pancreas (n = 2), kidney (n = 2) and others (n = 5). Chemotherapy was administered in 11 patients. The prescribed total dose was from 20 to 76 GyE (Radiobiological equivalent dose, RBE = 1.1), with the median dose of 65 GyE in 4 to 35 fractions. No PBT-related Common Terminology Criteria for Adverse Events Grade 4 or 5 toxicities were observed; the incidence of early PBT-related Grade 4 adverse events was 0% (95% confidence interval 0 to 6.38%). The most common Grade 3 toxicities were hematologic toxicity (12.5%) unlikely to be related to the PBT. One patient developed a left femoral neck fracture (Grade 3) at 14.5 months after PBT for chondrosarcoma of the left pelvis. The pathological findings showed no other malignancies, suggesting that it was possibly related to the PBT. In conclusion, the spot-scanning dedicated, synchrotron-based PBT system is feasible, but further studies on its long-term safety and efficacy are warranted. |
Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/70251 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 西岡 健太郎
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