HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Global Institution for Collaborative Research and Education : GI-CoRE >
Peer-reviewed Journal Articles, etc >

Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia

Files in This Item:
Ohkawara Manuscript revise170217_1.pdf286.47 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/70273

Title: Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia
Authors: Ohkawara, Ayako Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Ozawa, Makoto Browse this author
Chu, Duc-Huy Browse this author
Lam Thanh Nguyen Browse this author
Hiono, Takahiro Browse this author
Matsuno, Keita Browse this author →KAKEN DB
Kida, Hiroshi Browse this author →KAKEN DB
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: antigenicity
H5N8
hemagglutinin
highly pathogenic avian influenza virus
Issue Date: 17-May-2017
Publisher: John Wiley & Sons
Journal Title: Microbiology and immunology
Volume: 61
Issue: 5
Start Page: 149
End Page: 158
Publisher DOI: 10.1111/1348-0421.12478
PMID: 28370432
Abstract: H5 highly pathogenic avian influenza viruses (HPAIV) have spread in both poultry and wild birds since late 2003. Continued circulation of HPAIV in poultry in several regions of the world has led to antigenic drift. In the present study, we analyzed the antigenic properties of H5 HPAIV isolated in Asia using four neutralizing mAbs recognizing hemagglutinin, which were established using A/chicken/Kumamoto/1‐7/2014 (H5N8), belonging to clade 2.3.4.4 and also using polyclonal antibodies. Viruses of clades 1.1, 2.3.2.1, 2.3.4, and 2.3.4.4 had different reactivity patterns to the panel of mAbs, thereby indicating that the antigenicity of the viruses of clade 2.3.4.4 were similar but differed from the other clades. In particular, the antigenicity of the viruses of clade 2.3.4.4 differed from those of the viruses of clades 2.3.4 and 2.3.2.1, which suggests that the recent H5 HPAIV have further evolved antigenically divergent. In addition, reactivity of antiserum suggests that the antigenicity of viruses of clade 2.3.4.4 differed slightly among groups A, B, and C. Vaccines are still used in poultry in endemic countries, so the antigenicity of H5 HPAIV should be monitored continually to facilitate control of avian influenza. The panel of mAbs established in the present study will be useful for detecting antigenic drift in the H5 viruses that emerge from the current strains.
Rights: This is the peer reviewed version of the following article: "Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia", which has been published in final form at "https://doi.org/10.1111/1348-0421.12478" . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/70273
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

Export metadata:

OAI-PMH ( junii2 , jpcoar )


 

Feedback - Hokkaido University