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Radiographic temporal subtraction analysis can detect finger joint space narrowing progression in rheumatoid arthritis with clinical low disease activity

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/70448

Title: Radiographic temporal subtraction analysis can detect finger joint space narrowing progression in rheumatoid arthritis with clinical low disease activity
Authors: Okino, Taichi Browse this author
Kamishima, Tamotsu Browse this author →KAKEN DB
Sutherland, Kenneth Lee Browse this author →KAKEN DB
Fukae, Jun Browse this author
Narita, Akihiro Browse this author
Ichikawa, Shota Browse this author
Tanimura, Kazuhide Browse this author
Keywords: Rheumatoid arthritis
radiograph
joint space narrowing
clinical low disease activity
synovial vascularity
computer-based analysis
Issue Date: Apr-2018
Publisher: SAGE Publications
Journal Title: Acta radiologica
Volume: 59
Issue: 4
Start Page: 460
End Page: 467
Publisher DOI: 10.1177/0284185117721262
PMID: 28728431
Abstract: Background: Recent papers suggest that finger joints with positive synovial vascularity (SV) assessed by ultrasonography under clinical low disease activity (CLDA) in rheumatoid arthritis (RA) patients may cause joint space narrowing (JSN) progression. Purpose: To investigate the performance of a computer-based method by directly comparing with the conventional scoring method in terms of the detectability of JSN progression in hand radiography of RA patients with CLDA. Material and Methods: Fifteen RA patients (13 women, 2 men) with long-term sustained CLDA of > 2 years were included. Radiological progression of finger joints was measured or scored using the computer-based method which can detect JSN progression between two radiographic images as the joint space difference index (JSDI), as well as the Genant-modified Sharp score (GSS). We also quantitatively assessed SV of these joints using ultrasonography. Results: Out of 270 joints, we targeted 259 finger joints after excluding nine damaged joints (four ankylosis, three complete luxation, and two subluxation) and two improved joints according to the GSS results. The JSDI of finger joints with JSN progression was significantly higher than those without JSN progression (P = 0.018). The JSDI of finger joints with ultrasonographic SV was significantly higher than those without ultrasonographic SV (P = 0.004). Progression in JSDI showed stronger associations with ultrasonographic SV than progression in GSS (odds ratio [95% confidence interval]: 7.19 [3.37-15.36] versus 5.84 [2.76-12.33]). Conclusion: The computer-based method was comparable to the conventional scoring method regarding the detectability of JSN progression in RA patients with CLDA.
Rights: T Okino, T Kamishima, K Sutherland, J Fukase, A Narita, S Ichikawa, K Tanimura, Radiographic temporal subtraction analysis can detect finger joint space narrowing progression in rheumatoid arthritis with clinical low disease activity, Acta radiologica, Vol 59, Issue 4, 460-467. Copyright © 2018 The Author(s). Reprinted by permission of SAGE Publications.
Type: article (author version)
URI: http://hdl.handle.net/2115/70448
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神島 保

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