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Post-partum podocyturia following pre-eclamptic pregnancy

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Title: Post-partum podocyturia following pre-eclamptic pregnancy
Other Titles: Postpartum podocyturia following preeclamptic pregnancy
Authors: Furuta, Itsuko Browse this author →KAKEN DB
Zhai, Tianyue Browse this author
Umazume, Takeshi Browse this author →KAKEN DB
Ishikawa, Satoshi Browse this author
Hosokawa, Ami Browse this author
Kojima, Takashi Browse this author
Chiba, Kentaro Browse this author
Yamada, Takahiro Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: nephrin
podocyte injury
proteinuric disease
Issue Date: Jun-2017
Publisher: John Wiley & Sons
Journal Title: Journal of Obstetrics and Gynaecology Research
Volume: 43
Issue: 6
Start Page: 1008
End Page: 1013
Publisher DOI: 10.1111/jog.13326
PMID: 28621045
Abstract: Aim: Urine podocin mRNA expression and urine podocin : nephrin mRNA expression ratio (PNR) increase with increasing proteinuria during pregnancy complicated with pre-eclampsia (PE). This suggests that urine podocytes with reduced nephrin mRNA expression are abundant in pathological podocyturia. The aim of this study was therefore to determine post-partum changes in podocyturia and PNR in relation to proteinuria after pre-eclampsia (PE). Methods: A total of 137 peripartum urine specimens, consisting of 72 and 65 from 24 and 30 women with PE and normotensive control pregnancies (NCP), respectively, were studied. Determination of urine protein and creatinine concentration and quantitative analysis of podocyte-specific podocin and nephrin mRNA expression were carried out using reverse transcription-polymerase chain reaction in pelleted urine samples. Podocyturia was monitored via urine podocin mRNA expression. Podocyturia and proteinuria were normalized by urine creatinine concentration. Results: Podocyturia and urine PNR decreased with decreasing proteinuria as well as with increasing time after delivery in the urine from PE women. In physiological proteinuria (i.e. protein : creatinine ratio [P/Cr] 0.005-0.1 mg/mg), however, both podocyturia and PNR were significantly greater in the urine from PE women compared with NPC women, although P/Cr was similar between the groups (median, 0.037 mg/mg for PE vs 0.029 mg/mg for NCP). Conclusions: Podocyturia decreases with decreasing proteinuria in PE women after childbirth. In PE women, however, pathological podocyturia consisting of podocytes with decreased nephrin mRNA expression persisted even after proteinuria decreased to a level similar to that in NCP women.
Rights: This is the peer reviewed version of the following article: Itsuko Furuta, Tianyue Zhai, Takeshi Umazume, Satoshi Ishikawa, Ami Hosokawa, Takashi Kojima, Kentaro Chiba, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami, Post‐partum podocyturia following pre‐eclamptic pregnancy, The Journal of Obstetrics and Gynaecology Research, Volume43, Issue6, 2017, pp.1008-1013, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 古田 伊都子

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