| Title: | Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation |
| Other Titles: | HHV-6 encephalitis/myelitis after HSCT |
| Authors: | Miyashita, Naohiro Browse this author |
| Endo, Tomoyuki Browse this author |
| Onozawa, Masahiro Browse this author →KAKEN DB |
| Hashimoto, Daigo Browse this author |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Fujimoto, Katsuya Browse this author |
| Kahata, Kaoru Browse this author |
| Sugita, Junichi Browse this author |
| Goto, Hideki Browse this author |
| Matsukawa, Toshihiro Browse this author |
| Hashino, Satoshi Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | hematopoietic stem cell transplantation |
| human herpesvirus 6 |
| mycophenolate mofetil |
| Issue Date: | Jun-2017 |
| Publisher: | Wiley |
| Journal Title: | Transplant infectious disease |
| Volume: | 19 |
| Issue: | 3 |
| Start Page: | e12682 |
| Publisher DOI: | 10.1111/tid.12682 |
| PMID: | 28207973 |
| Abstract: | Background: Human herpesvirus 6 (HHV-6) encephalitis/myelitis is now a well-known complication after allogeneic stem cell transplantation (allo-HSCT), particularly after cord blood transplantation (CBT). In this study, we evaluated the risk factors of HHV-6 encephalitis/myelitis. Methods: We evaluated 253 patients who received allo-HSCT from 2007 to 2015 at our institute. HHV-6 encephalitis/myelitis was defined as HHV-6 DNA detection in the cerebrospinal fluid or peripheral blood by polymerase chain reaction in the presence of typical manifestations without other concurrent condition that led to the manifestations. Results: HHV-6 encephalitis/myelitis occurred in 11 patients (4.5%) (9 encephalitis, 3.7%; 2 myelitis, 0.8%). Multivariate analysis showed that CBT, mycophenolate mofetil (MMF) for graft-versus-host disease prophylaxis, history of allogeneic hematopoietic stem cell transplantation (allo-HSCT), and engraftment syndrome (ES) were significantly associated with incidence of HHV-6 encephalitis/myelitis (P=.025, P=.017, P=.017, and P=.014, respectively). Conclusion: Although it has been shown that CBT, ES, and history of allo-HSCT are risk factors for HHV-6 encephalitis/myelitis, our study demonstrated MMF is also a risk factor for the disease. |
| Rights: | This is the peer reviewed version of the following article: Miyashita N, Endo T, Onozawa M, et al. Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2017;19:e12682, which has been published in final form at https://doi.org/10.1111/tid.12682. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/70643 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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