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Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation

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Title: Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation
Other Titles: HHV-6 encephalitis/myelitis after HSCT
Authors: Miyashita, Naohiro Browse this author
Endo, Tomoyuki Browse this author
Onozawa, Masahiro Browse this author →KAKEN DB
Hashimoto, Daigo Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Fujimoto, Katsuya Browse this author
Kahata, Kaoru Browse this author
Sugita, Junichi Browse this author
Goto, Hideki Browse this author
Matsukawa, Toshihiro Browse this author
Hashino, Satoshi Browse this author →KAKEN DB
Teshima, Takanori Browse this author →KAKEN DB
Keywords: hematopoietic stem cell transplantation
human herpesvirus 6
mycophenolate mofetil
Issue Date: Jun-2017
Publisher: Wiley
Journal Title: Transplant infectious disease
Volume: 19
Issue: 3
Start Page: e12682
Publisher DOI: 10.1111/tid.12682
PMID: 28207973
Abstract: Background: Human herpesvirus 6 (HHV-6) encephalitis/myelitis is now a well-known complication after allogeneic stem cell transplantation (allo-HSCT), particularly after cord blood transplantation (CBT). In this study, we evaluated the risk factors of HHV-6 encephalitis/myelitis. Methods: We evaluated 253 patients who received allo-HSCT from 2007 to 2015 at our institute. HHV-6 encephalitis/myelitis was defined as HHV-6 DNA detection in the cerebrospinal fluid or peripheral blood by polymerase chain reaction in the presence of typical manifestations without other concurrent condition that led to the manifestations. Results: HHV-6 encephalitis/myelitis occurred in 11 patients (4.5%) (9 encephalitis, 3.7%; 2 myelitis, 0.8%). Multivariate analysis showed that CBT, mycophenolate mofetil (MMF) for graft-versus-host disease prophylaxis, history of allogeneic hematopoietic stem cell transplantation (allo-HSCT), and engraftment syndrome (ES) were significantly associated with incidence of HHV-6 encephalitis/myelitis (P=.025, P=.017, P=.017, and P=.014, respectively). Conclusion: Although it has been shown that CBT, ES, and history of allo-HSCT are risk factors for HHV-6 encephalitis/myelitis, our study demonstrated MMF is also a risk factor for the disease.
Rights: This is the peer reviewed version of the following article: Miyashita N, Endo T, Onozawa M, et al. Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2017;19:e12682, which has been published in final form at https://doi.org/10.1111/tid.12682. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/70643
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮下 直洋

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