| Title: | Endoscopic ultrasonography features of gastric mucosal cobblestone-like changes from a proton-pump inhibitor |
| Authors: | Miyamoto, Shuichi Browse this author |
| Kudo, Takahiko Browse this author |
| Kato, Mototsugu Browse this author →KAKEN DB |
| Matsuda, Kana Browse this author |
| Abiko, Satoshi Browse this author |
| Tsuda, Momoko Browse this author |
| Mizushima, Takeshi Browse this author |
| Yamamoto, Keiko Browse this author |
| Ono, Shoko Browse this author |
| Shimizu, Yuichi Browse this author →KAKEN DB |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | Endoscopic ultrasonography |
| Cobblestone-like changes |
| Proton-pump inhibitor |
| Issue Date: | Jun-2017 |
| Publisher: | Springer |
| Journal Title: | Clinical journal of gastroenterology |
| Volume: | 10 |
| Issue: | 3 |
| Start Page: | 220 |
| End Page: | 223 |
| Publisher DOI: | 10.1007/s12328-017-0724-5 |
| PMID: | 28265894 |
| Abstract: | A 68-year-old man with no symptoms presented to Hokkaido University Hospital for esophagogastroduodenoscopy screening. He had a history of Helicobacter pylori eradication. Initial esophagogastroduodenoscopy showed no gastric cobblestone-like mucosa or gastric cracked mucosa. After 1 year, he received esomeprazole (20 mg) once daily for heartburn at another hospital. Esophagogastroduodenoscopy was performed after 2 years of esomeprazole administration. Endoscopic findings showed that after H. pylori eradication, according to the Kyoto classification, gastric cobblestone-like mucosa presented in the gastric body area. Dilation of the oval crypt opening and intervening part in the gastric cobblestone-like mucosa was detected by endoscopy with narrow band imaging. Endoscopic ultrasonography revealed a thick gastric second layer and sporadic small a-echoic lesions in the low-echoic thickened second layer in the gastric cobblestone-like mucosa. The gastric cobblestone-like mucosa biopsy specimen showed parietal cell protrusions and oxyntic gland dilatations. Recently, we reported that gastric mucosal changes such as gastric cracked mucosa and gastric cobblestone-like mucosa were caused by protonpump inhibitors; however, the gastric cobblestone-like mucosa was not examined by endoscopic ultrasonography. In this case, endoscopic ultrasonography findings suggested that oxyntic gland dilatations caused the elevated gastric mucosa, such as gastric cobblestone-like mucosa, from the use of proton-pump inhibitors. |
| Rights: | Clinical journal of gastroenterology |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/70647 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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