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Endoscopic ultrasonography features of gastric mucosal cobblestone-like changes from a proton-pump inhibitor

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Title: Endoscopic ultrasonography features of gastric mucosal cobblestone-like changes from a proton-pump inhibitor
Authors: Miyamoto, Shuichi Browse this author
Kudo, Takahiko Browse this author
Kato, Mototsugu Browse this author →KAKEN DB
Matsuda, Kana Browse this author
Abiko, Satoshi Browse this author
Tsuda, Momoko Browse this author
Mizushima, Takeshi Browse this author
Yamamoto, Keiko Browse this author
Ono, Shoko Browse this author
Shimizu, Yuichi Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Endoscopic ultrasonography
Cobblestone-like changes
Proton-pump inhibitor
Issue Date: Jun-2017
Publisher: Springer
Journal Title: Clinical journal of gastroenterology
Volume: 10
Issue: 3
Start Page: 220
End Page: 223
Publisher DOI: 10.1007/s12328-017-0724-5
PMID: 28265894
Abstract: A 68-year-old man with no symptoms presented to Hokkaido University Hospital for esophagogastroduodenoscopy screening. He had a history of Helicobacter pylori eradication. Initial esophagogastroduodenoscopy showed no gastric cobblestone-like mucosa or gastric cracked mucosa. After 1 year, he received esomeprazole (20 mg) once daily for heartburn at another hospital. Esophagogastroduodenoscopy was performed after 2 years of esomeprazole administration. Endoscopic findings showed that after H. pylori eradication, according to the Kyoto classification, gastric cobblestone-like mucosa presented in the gastric body area. Dilation of the oval crypt opening and intervening part in the gastric cobblestone-like mucosa was detected by endoscopy with narrow band imaging. Endoscopic ultrasonography revealed a thick gastric second layer and sporadic small a-echoic lesions in the low-echoic thickened second layer in the gastric cobblestone-like mucosa. The gastric cobblestone-like mucosa biopsy specimen showed parietal cell protrusions and oxyntic gland dilatations. Recently, we reported that gastric mucosal changes such as gastric cracked mucosa and gastric cobblestone-like mucosa were caused by protonpump inhibitors; however, the gastric cobblestone-like mucosa was not examined by endoscopic ultrasonography. In this case, endoscopic ultrasonography findings suggested that oxyntic gland dilatations caused the elevated gastric mucosa, such as gastric cobblestone-like mucosa, from the use of proton-pump inhibitors.
Rights: Clinical journal of gastroenterology
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮本 秀一

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