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Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study : Design, methods and baseline results in 14 642 women

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Title: Comparison of human papillomavirus genotyping and cytology triage, COMPACT Study : Design, methods and baseline results in 14 642 women
Authors: Aoyama-Kikawa, Satomi Browse this author
Fujita, Hiromasa Browse this author
Hanley, Sharon J.B Browse this author
Kasamo, Mitsunori Browse this author
Kikuchi, Kokichi Browse this author
Torigoe, Toshihiko Browse this author
Matsuno, Yoshihiro Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Sasaki, Takayuki Browse this author
Matsuura, Motoki Browse this author
Kato, Yasuhito Browse this author
Dong, Peixin Browse this author →KAKEN DB
Watari, Hidemichi Browse this author →KAKEN DB
Saito, Tsuyoshi Browse this author
Sengoku, Kazuo Browse this author →KAKEN DB
Sakuragi, Noriaki Browse this author →KAKEN DB
Issue Date: Jun-2018
Publisher: Wiley
Journal Title: Cancer Science
Volume: 109
Issue: 6
Start Page: 2003
End Page: 2012
Publisher DOI: 10.1111/cas.13608
Abstract: Although cytology‐based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high‐grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV‐positive women to avoid over‐referral to colposcopy may be setting specific. As Japan requires data that have been generated domestically to modify screening guidelines, we conducted a 3‐year prospective study, COMparison of HPV genotyping And Cytology Triage (COMPACT), to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening. In total, 14 642 women aged 20 to 69 years undergoing routine screening at 3 centers in Hokkaido were enrolled. Conventional cytology and HPV testing were carried out. Women with abnormal cytology or HPV16/18 positivity underwent colposcopy. Those with 12 other high‐risk (hr) HPV types underwent repeat cytology after 6 months. Primary study endpoints were detection of high‐grade cervical disease defined as CIN2/CIN3 or greater as determined by consensus pathology. Prevalence of cytological abnormalities was 2.4%. hrHPV, HPV 16, and HPV 18 were detected in 4.6%, 0.9%, and 0.3% of women, respectively. HPV16/18 were detected in all (8/8) invasive cervical cancers and in all (2/2) adenocarcinomas in situ. Both cytological abnormalities and hrHPV positivity declined with increasing age. This is the first Japanese study to investigate the role of partial genotyping and cytology in an HPV‐based screening program. Results should help policy‐makers develop guidelines for future cervical screening programs and management of cervical abnormalities based on HPV genotype.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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