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2万人規模の出生コーホートと,500人規模の小コーホートからなる北海道スタディが目指してきたもの : 環境と子どもの健康 : 先天異常・発達・アレルギーの15年におよぶ経験と成果

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Title: 2万人規模の出生コーホートと,500人規模の小コーホートからなる北海道スタディが目指してきたもの : 環境と子どもの健康 : 先天異常・発達・アレルギーの15年におよぶ経験と成果
Other Titles: Importance of Two Birth Cohorts (n=20,926 and n=514) : 15 Years' Experience of the Hokkaido Study on Environment and Children's Health : Malformation, Development and Allergy
Authors: 岸, 玲子1 Browse this author →KAKEN DB
荒木, 敦子2 Browse this author →KAKEN DB
宮下, ちひろ3 Browse this author →KAKEN DB
伊藤, 佐智子4 Browse this author →KAKEN DB
湊屋, 街子5 Browse this author →KAKEN DB
小林, 澄貴6 Browse this author →KAKEN DB
山﨑, 圭子7 Browse this author →KAKEN DB
アイツバマイ, ゆふ8 Browse this author →KAKEN DB
三浦, りゅう9 Browse this author →KAKEN DB
田村, 菜穂美10 Browse this author →KAKEN DB
Authors(alt): Kishi, Reiko1
Araki, Atsuko2
Miyashita, Chihiro3
Itoh, Sachiko4
Minatoya, Machiko5
Kobayashi, Sumitaka6
Yamazaki, Keiko7
Ait Bamai, Yu8
Miura, Ryu9
Tamura, Naomi10
Keywords: environmental chemicals
birth cohort study
Developmental Origin Health and Diseases hypothesis
endocrine disruptors
Issue Date: 31-May-2018
Publisher: 日本衛生学会
Journal Title: 日本衛生学雑誌
Journal Title(alt): Japanese Journal of Hygiene
Volume: 73
Issue: 2
Start Page: 164
End Page: 177
Publisher DOI: 10.1265/jjh.73.164
PMID: 29848869
Abstract: Since "Our Stolen Future" by Theo Colborn was published in 1996, global interest on the impact of chemical substances, such as the endocrine-disrupting action of chemicals, has increased. In Japan, "The Hokkaido Study on Environment and Children's Health: Malformation, Development and Allergy" was launched in 2001. It was a model of Japan Environment and Children's Study of the Ministry of the Environment. In a large-scale, Hokkaido cohort, we obtained the consent of 20,926 mothers at the organogenesis stage with the cooperation of 37 obstetrics clinics in Hokkaido. We tracked the effects of endocrine disruptors on developmental disorders. In a small-scale Sapporo cohort, we observed in detail the neuropsychiatric development of children with the consent of 514 mothers in their late pregnancy. We examined how prenatal exposure to low concentrations of environmental chemicals affect the development of organs and the postnatal development of children. Maternal exposure to POPs, such as PCB/dioxins and perfluorinated alkyl substances, has affected not only children's birth size, thyroid functions, and sex hormone levels, but also postnatal neurodevelopment, infection, and allergy among others. The associations of short-half-life substances, such as DEHP and BPA, with obesity, ASD, and ADHD have been investigated. Gene-environment interactions have been found for smoking, caffeine, folic acid, and PCB/dioxin. In 2015, our center was officially designated as the WHO Collaborating Centre for Environmental Health and Prevention of Chemical Hazards, and we continue to the contribute to the global perspectives of child health.
Description: ミニ特集 小児環境保健疫学研究のパラダイム
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木 敦子

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