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2万人規模の出生コーホートと,500人規模の小コーホートからなる北海道スタディが目指してきたもの : 環境と子どもの健康 : 先天異常・発達・アレルギーの15年におよぶ経験と成果

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タイトル: 2万人規模の出生コーホートと,500人規模の小コーホートからなる北海道スタディが目指してきたもの : 環境と子どもの健康 : 先天異常・発達・アレルギーの15年におよぶ経験と成果
その他のタイトル: Importance of Two Birth Cohorts (n=20,926 and n=514) : 15 Years' Experience of the Hokkaido Study on Environment and Children's Health : Malformation, Development and Allergy
著者: 岸, 玲子 著作を一覧する
荒木, 敦子 著作を一覧する
宮下, ちひろ 著作を一覧する
伊藤, 佐智子 著作を一覧する
湊屋, 街子 著作を一覧する
小林, 澄貴 著作を一覧する
山﨑, 圭子 著作を一覧する
アイツバマイ, ゆふ 著作を一覧する
三浦, りゅう 著作を一覧する
田村, 菜穂美 著作を一覧する
キーワード: environmental chemicals
birth cohort study
Developmental Origin Health and Diseases hypothesis
endocrine disruptors
発行日: 2018年 5月31日
出版者: 日本衛生学会 = The Japanese Society for Hygiene
誌名: 日本衛生学雑誌 = Japanese Journal of Hygiene
巻: 73
号: 2
開始ページ: 164
終了ページ: 177
出版社 DOI: 10.1265/jjh.73.164
抄録: Since "Our Stolen Future" by Theo Colborn was published in 1996, global interest on the impact of chemical substances, such as the endocrine-disrupting action of chemicals, has increased. In Japan, "The Hokkaido Study on Environment and Children's Health: Malformation, Development and Allergy" was launched in 2001. It was a model of Japan Environment and Children's Study of the Ministry of the Environment. In a large-scale, Hokkaido cohort, we obtained the consent of 20,926 mothers at the organogenesis stage with the cooperation of 37 obstetrics clinics in Hokkaido. We tracked the effects of endocrine disruptors on developmental disorders. In a small-scale Sapporo cohort, we observed in detail the neuropsychiatric development of children with the consent of 514 mothers in their late pregnancy. We examined how prenatal exposure to low concentrations of environmental chemicals affect the development of organs and the postnatal development of children. Maternal exposure to POPs, such as PCB/dioxins and perfluorinated alkyl substances, has affected not only children's birth size, thyroid functions, and sex hormone levels, but also postnatal neurodevelopment, infection, and allergy among others. The associations of short-half-life substances, such as DEHP and BPA, with obesity, ASD, and ADHD have been investigated. Gene-environment interactions have been found for smoking, caffeine, folic acid, and PCB/dioxin. In 2015, our center was officially designated as the WHO Collaborating Centre for Environmental Health and Prevention of Chemical Hazards, and we continue to the contribute to the global perspectives of child health.
記述: ミニ特集 小児環境保健疫学研究のパラダイム
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 荒木 敦子


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