HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Sphingolipids in cardiovascular and cerebrovascular systems : Pathological implications and potential therapeutic targets

Creative Commons License

Files in This Item:
E2_WJC-5-75.pdf913.56 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/70761

Title: Sphingolipids in cardiovascular and cerebrovascular systems : Pathological implications and potential therapeutic targets
Authors: Kawabori, Masahito Browse this author →KAKEN DB
Kacimi, Rachid Browse this author
Karliner, Joel S Browse this author
Yenari, Midori A Browse this author
Keywords: Sphingolipids
Sphingosine-1-phosphate
Sphingosine kinase
Ceramide kinase
Issue Date: 26-Apr-2013
Publisher: Baishideng Publishing Group
Journal Title: World Journal of Cardiology
Volume: 5
Issue: 4
Start Page: 75
End Page: 86
Publisher DOI: 10.4330/wjc.v5.i4.75
Abstract: The sphingolipid metabolites ceramide, sphingosine, and sphingosine-1-phosphate (S1P) and its enzyme sphingosine kinase (SphK) play an important role in the regulation of cell proliferation, survival, inflammation, and cell death. Ceramide and sphingosine usually inhibit proliferation and promote apoptosis, while its metabolite S1P phosphorylated by SphK stimulates growth and suppresses apoptosis. Because these metabolites are interconvertible, it has been proposed that it is not the absolute amounts of these metabolites but rather their relative levels that determine cell fate. The relevance of this "sphingolipid rheostat" and its role in regulating cell fate has been borne out by work in many labs using many different cell types and experimental manipulations. A central finding of these studies is that SphK is a critical regulator of the sphingolipid rheostat, as it not only produces the pro-growth, anti-apoptotic messenger S1P, but also decreases levels of pro-apoptotic ceramide and sphingosine. Activation of bioactive sphingolipid S1P signaling has emerged as a critical protective pathway in response to acute ischemic injury in both cardiac and cerebrovascular disease, and these observations have considerable relevance for future potential therapeutic targets.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/70761
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 川堀 真人

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University