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Sphingolipids in cardiovascular and cerebrovascular systems : Pathological implications and potential therapeutic targets
This item is licensed under:Creative Commons Attribution-NonCommercial 4.0 International
| Title: | Sphingolipids in cardiovascular and cerebrovascular systems : Pathological implications and potential therapeutic targets |
| Authors: | Kawabori, Masahito Browse this author →KAKEN DB | | Kacimi, Rachid Browse this author | | Karliner, Joel S Browse this author | | Yenari, Midori A Browse this author |
| Keywords: | Sphingolipids | | Sphingosine-1-phosphate | | Sphingosine kinase | | Ceramide kinase |
| Issue Date: | 26-Apr-2013 |
| Publisher: | Baishideng Publishing Group |
| Journal Title: | World Journal of Cardiology |
| Volume: | 5 |
| Issue: | 4 |
| Start Page: | 75 |
| End Page: | 86 |
| Publisher DOI: | 10.4330/wjc.v5.i4.75 |
| Abstract: | The sphingolipid metabolites ceramide, sphingosine, and sphingosine-1-phosphate (S1P) and its enzyme sphingosine kinase (SphK) play an important role in the regulation of cell proliferation, survival, inflammation, and cell death. Ceramide and sphingosine usually inhibit proliferation and promote apoptosis, while its metabolite S1P phosphorylated by SphK stimulates growth and suppresses apoptosis. Because these metabolites are interconvertible, it has been proposed that it is not the absolute amounts of these metabolites but rather their relative levels that determine cell fate. The relevance of this "sphingolipid rheostat" and its role in regulating cell fate has been borne out by work in many labs using many different cell types and experimental manipulations. A central finding of these studies is that SphK is a critical regulator of the sphingolipid rheostat, as it not only produces the pro-growth, anti-apoptotic messenger S1P, but also decreases levels of pro-apoptotic ceramide and sphingosine. Activation of bioactive sphingolipid S1P signaling has emerged as a critical protective pathway in response to acute ischemic injury in both cardiac and cerebrovascular disease, and these observations have considerable relevance for future potential therapeutic targets. |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70761 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 川堀 真人
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