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Influenza A Virus M2 Protein: Roles from Ingress to Egress

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Title: Influenza A Virus M2 Protein: Roles from Ingress to Egress
Authors: Manzoor, Rashid Browse this author
Igarashi, Manabu Browse this author
Takada, Ayato Browse this author
Keywords: influenza A virus
M2 protein
pathogenicity
Issue Date: Dec-2017
Publisher: MDPI
Journal Title: International Journal of Molecular Sciences
Volume: 18
Issue: 12
Start Page: 2649
Publisher DOI: 10.3390/ijms18122649
Abstract: Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence extensively studied, ion channel proteins. The M2 ion channel activity is not only essential for virus replication, but also involved in modulation of cellular homeostasis in a variety of ways. It is also the target for ion channel inhibitors, i.e., anti-influenza drugs. Thus far, several studies have been conducted to elucidate its biophysical characteristics, structure-function relationships of the ion channel, and the M2-host interactome. In this review, we discuss M2 protein synthesis and assembly into an ion channel, its roles in IAV replication, and the pathophysiological impact on the host cell.
Rights: © 2017 Rashid Manzoor, Manabu Igarashi, and Ayato Takada
https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/70806
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: RASHID MANZOOR

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