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Influenza A Virus M2 Protein: Roles from Ingress to Egress
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Influenza A Virus M2 Protein: Roles from Ingress to Egress |
| Authors: | Manzoor, Rashid Browse this author | | Igarashi, Manabu Browse this author | | Takada, Ayato Browse this author |
| Keywords: | influenza A virus | | M2 protein | | pathogenicity |
| Issue Date: | Dec-2017 |
| Publisher: | MDPI |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 18 |
| Issue: | 12 |
| Start Page: | 2649 |
| Publisher DOI: | 10.3390/ijms18122649 |
| Abstract: | Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence extensively studied, ion channel proteins. The M2 ion channel activity is not only essential for virus replication, but also involved in modulation of cellular homeostasis in a variety of ways. It is also the target for ion channel inhibitors, i.e., anti-influenza drugs. Thus far, several studies have been conducted to elucidate its biophysical characteristics, structure-function relationships of the ion channel, and the M2-host interactome. In this review, we discuss M2 protein synthesis and assembly into an ion channel, its roles in IAV replication, and the pathophysiological impact on the host cell. |
| Rights: | © 2017 Rashid Manzoor, Manabu Igarashi, and Ayato Takada | | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70806 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: RASHID MANZOOR
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