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Hokkaido University Collection of Scholarly and Academic Papers >
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Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages
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| Title: | Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages |
| Authors: | Wijekoon, Suranji Browse this author | | Bwalya, Eugene C. Browse this author | | Fang, Jing Browse this author | | Kim, Sangho Browse this author | | Hosoya, Kenji Browse this author | | Okumura, Masahiro Browse this author →KAKEN DB |
| Keywords: | cytokine | | dog | | osteoclast | | osteoclastogenesis | | rheumatoid arthritis |
| Issue Date: | Dec-2017 |
| Publisher: | 公益社団法人 日本獣医学会 |
| Journal Title: | Journal of veterinary medical science |
| Volume: | 79 |
| Issue: | 12 |
| Start Page: | 2030 |
| End Page: | 2035 |
| Publisher DOI: | 10.1292/jvms.17-0393 |
| Abstract: | The aim of this study was to investigate osteoclastogenic properties of inflammatory cytokines at different time-points of osteoclastogenesis. Bone marrow-derived macrophages from five healthy dogs were stimulated with the macrophage colony-stimulating factor, receptor activator of nuclear factor-kappa B ligand and inflammatory cytokines such as interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha and IL-17. Osteoclasts (OC) formation and function were enhanced with TNF-alpha regardless of temporal differences. But in contrast, IL-1 beta suppressed the osteoclastogenesis at early phase of the process while upregulating at the late phase. Furthermore, differentiation of OC precursors into OC was suppressed at high concentrations of IL-17. Collectively, the results revealed that suppressing TNF-alpha would be a promising strategy to inhibit inflammation-associated bone destruction in dogs. |
| Rights: | © 2017 The Japanese Society of Veterinary Science | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70810 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: Suranji WIJEKOON
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