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Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages

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Title: Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages
Authors: Wijekoon, Suranji Browse this author
Bwalya, Eugene C. Browse this author
Fang, Jing Browse this author
Kim, Sangho Browse this author
Hosoya, Kenji Browse this author
Okumura, Masahiro Browse this author →KAKEN DB
Keywords: cytokine
dog
osteoclast
osteoclastogenesis
rheumatoid arthritis
Issue Date: Dec-2017
Publisher: 公益社団法人 日本獣医学会
Journal Title: Journal of veterinary medical science
Volume: 79
Issue: 12
Start Page: 2030
End Page: 2035
Publisher DOI: 10.1292/jvms.17-0393
Abstract: The aim of this study was to investigate osteoclastogenic properties of inflammatory cytokines at different time-points of osteoclastogenesis. Bone marrow-derived macrophages from five healthy dogs were stimulated with the macrophage colony-stimulating factor, receptor activator of nuclear factor-kappa B ligand and inflammatory cytokines such as interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha and IL-17. Osteoclasts (OC) formation and function were enhanced with TNF-alpha regardless of temporal differences. But in contrast, IL-1 beta suppressed the osteoclastogenesis at early phase of the process while upregulating at the late phase. Furthermore, differentiation of OC precursors into OC was suppressed at high concentrations of IL-17. Collectively, the results revealed that suppressing TNF-alpha would be a promising strategy to inhibit inflammation-associated bone destruction in dogs.
Rights: © 2017 The Japanese Society of Veterinary Science
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/70810
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Suranji WIJEKOON

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