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Close pathological correlations between chronic kidney disease and reproductive organ-associated abnormalities in female cotton rats

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Title: Close pathological correlations between chronic kidney disease and reproductive organ-associated abnormalities in female cotton rats
Authors: Ichii, Osamu Browse this author →KAKEN DB
Nakamura, Teppei Browse this author
Irie, Takao Browse this author
Kouguchi, Hirokazu Browse this author →KAKEN DB
Sotozaki, Kozue Browse this author
Horino, Taro Browse this author
Sunden, Yuji Browse this author →KAKEN DB
Elewa, Yaser Hosny Ali Browse this author →ORCID
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: Cotton rat
chronic kidney disease
sex hormone
pyometra
ovariectomy
histopathology
Issue Date: Mar-2018
Publisher: SAGE Publications
Journal Title: Experimental biology and medicine
Volume: 243
Issue: 5
Start Page: 418
End Page: 427
Publisher DOI: 10.1177/1535370218758250
Abstract: Cotton rat (Sigmodon hispidus) is a useful experimental rodent for the study of human infectious diseases. We previously clarified that cotton rats, particularly females, developed chronic kidney disease characterized by cystic lesions, inflammation, and fibrosis. The present study investigated female-associated factors for chronic kidney disease development in cotton rats. Notably, female cotton rats developed separation of the pelvic symphysis and hypertrophy in the vaginal parts of the cervix with age, which strongly associated with pyometra. The development of pyometra closely associated with the deterioration of renal dysfunction or immunological abnormalities was indicated by blood urea nitrogen and serum creatinine or spleen weight and serum albumin/globulin ratio, respectively. These parameters for renal dysfunction and immunological abnormalities were statistically correlated. These phenotypes found in the female reproductive organs were completely inhibited by ovariectomy. Further, the female cotton rats with pyometra tended to show more severe chronic kidney disease phenotypes and immunological abnormalities than those without pyometra; these changes were inhibited in ovariectomized cotton rats. With regard to renal histopathology, cystic lesions, inflammation, and fibrosis were ameliorated by ovariectomy. Notably, the immunostaining intensity of estrogen receptor and estrogen receptor were weak in the healthy kidneys, but both estrogen receptors were strongly induced in the renal tubules showing cystic changes. In conclusion, the close correlations among female reproductive organ-associated abnormalities, immunological abnormalities, and renal dysfunction characterize the chronic kidney disease features of female cotton rats. Thus, the cotton rat is a unique rodent model to elucidate the pathological crosstalk between chronic kidney disease and sex-related factors.
Rights: Osamu Ichii, Teppei Nakamura, Takao Irie, Hirokazu Kouguchi, Kozue Sotozaki, Taro Horino, Yuji Sunden, Yaser Hosny Ali Elewa, Yasuhiro Kon, Close pathological correlations between chronic kidney disease and reproductive organ-associated abnormalities in female cotton rats, Experimental Biology and Medicine (Volume 243 Issue 5) pp. 418-427. Copyright c [2018] (The Society for Experimental Biology and Medicine). Reprinted by permission of SAGE Publications.
Type: article (author version)
URI: http://hdl.handle.net/2115/70867
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 市居 修

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