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Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study : The Hokkaido Study on Environment and Children's Health

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Title: Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study : The Hokkaido Study on Environment and Children's Health
Authors: Hanaoka, Tomoyuki Browse this author
Tamura, Naomi Browse this author →KAKEN DB
Ito, Kumiko Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Ikeno, Tamiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Ito, Sachiko Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Cho, Kazutoshi Browse this author →KAKEN DB
Endo, Toshiaki Browse this author →KAKEN DB
Baba, Tsuyoshi Browse this author
Miyamoto, Toshinobu Browse this author →KAKEN DB
Sengoku, Kazuo Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
other members of the Hokkaido Study on Environment and Children's Health Browse this author
Keywords: Hokkaido Study on Environment and Children's Health
prospective studies
cohort studies
birth defects
growth retardation
Issue Date: 5-Mar-2018
Publisher: Japan Epidemiological Association
Journal Title: Journal of epidemiology
Volume: 28
Issue: 3
Start Page: 125
End Page: 132
Publisher DOI: 10.2188/jea.JE20160108
Abstract: Background: Prevalence rates of all anomalies classified as birth defects, including those identified before the 22nd gestational week, are limited in published reports, including those from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). In our birth cohort study, we collected the data for all birth defects after 12 weeks of gestation. Methods: Subjects in this study comprised 19,244 pregnant women who visited one of 37 associated hospitals in the Hokkaido Prefecture from 2003 through 2012, and completed follow-up. All birth defects after 12 weeks of gestation, including 55 marker anomalies associated with environmental chemical exposures, were recorded. We examined parental risk factors for birth defects and the association between birth defects and risk of growth retardation. Results: Prevalence of all birth defects was 18.9/1,000 births. The proportion of patients with birth defects delivered between 12 and 21 weeks of gestation was approximately one-tenth of all patients with birth defects. Among those with congenital malformation of the nerve system, 39% were delivered before 22 weeks of gestation. All patients with anencephaly and encephalocele were delivered before 22 weeks of gestation. We observed different patterns of parental risk factors between birth defect cases included in ISBDSR and cases not included. Cases included in ISBDSR were associated with an increased risk of preterm birth. Cases not included in ISBDSR were associated with an increased risk of being small for gestational age at term. Conclusions: Data from our study complemented the data from ICBDSR. We recommend that birth defects not included in ICBDSR also be analyzed to elucidate the etiology of birth defects.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/70869
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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