| Title: | Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study : The Hokkaido Study on Environment and Children's Health |
| Authors: | Hanaoka, Tomoyuki Browse this author |
| Tamura, Naomi Browse this author →KAKEN DB |
| Ito, Kumiko Browse this author |
| Sasaki, Seiko Browse this author →KAKEN DB |
| Araki, Atsuko Browse this author →KAKEN DB |
| Ikeno, Tamiko Browse this author →KAKEN DB |
| Miyashita, Chihiro Browse this author →KAKEN DB |
| Ito, Sachiko Browse this author |
| Minakami, Hisanori Browse this author →KAKEN DB |
| Cho, Kazutoshi Browse this author →KAKEN DB |
| Endo, Toshiaki Browse this author →KAKEN DB |
| Baba, Tsuyoshi Browse this author |
| Miyamoto, Toshinobu Browse this author →KAKEN DB |
| Sengoku, Kazuo Browse this author →KAKEN DB |
| Kishi, Reiko Browse this author →KAKEN DB |
| other members of the Hokkaido Study on Environment and Children's Health Browse this author |
| Keywords: | Hokkaido Study on Environment and Children's Health |
| prospective studies |
| cohort studies |
| birth defects |
| growth retardation |
| Issue Date: | 5-Mar-2018 |
| Publisher: | Japan Epidemiological Association |
| Journal Title: | Journal of epidemiology |
| Volume: | 28 |
| Issue: | 3 |
| Start Page: | 125 |
| End Page: | 132 |
| Publisher DOI: | 10.2188/jea.JE20160108 |
| Abstract: | Background: Prevalence rates of all anomalies classified as birth defects, including those identified before the 22nd gestational week, are limited in published reports, including those from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). In our birth cohort study, we collected the data for all birth defects after 12 weeks of gestation. Methods: Subjects in this study comprised 19,244 pregnant women who visited one of 37 associated hospitals in the Hokkaido Prefecture from 2003 through 2012, and completed follow-up. All birth defects after 12 weeks of gestation, including 55 marker anomalies associated with environmental chemical exposures, were recorded. We examined parental risk factors for birth defects and the association between birth defects and risk of growth retardation. Results: Prevalence of all birth defects was 18.9/1,000 births. The proportion of patients with birth defects delivered between 12 and 21 weeks of gestation was approximately one-tenth of all patients with birth defects. Among those with congenital malformation of the nerve system, 39% were delivered before 22 weeks of gestation. All patients with anencephaly and encephalocele were delivered before 22 weeks of gestation. We observed different patterns of parental risk factors between birth defect cases included in ISBDSR and cases not included. Cases included in ISBDSR were associated with an increased risk of preterm birth. Cases not included in ISBDSR were associated with an increased risk of being small for gestational age at term. Conclusions: Data from our study complemented the data from ICBDSR. We recommend that birth defects not included in ICBDSR also be analyzed to elucidate the etiology of birth defects. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70869 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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