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Repeatability and reproducibility of quantitative contrast-enhanced ultrasonography for assessing duodenal perfusion in healthy dogs

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Title: Repeatability and reproducibility of quantitative contrast-enhanced ultrasonography for assessing duodenal perfusion in healthy dogs
Authors: Nisa, Khoirun Browse this author
Lim, Sue Yee Browse this author
Shinohara, Masayoshi Browse this author
Nagata, Noriyuki Browse this author
Sasaoka, Kazuyoshi Browse this author
Dermlim, Angkhana Browse this author
Leela-Arporn, Rommaneeya Browse this author
Morita, Tomoya Browse this author
Yokoyama, Nozomu Browse this author
Osuga, Tatsuyuki Browse this author
Sasaki, Noboru Browse this author
Morishita, Keitaro Browse this author →KAKEN DB
Nakamura, Kensuke Browse this author
Ohta, Hiroshi Browse this author →KAKEN DB
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: canine
duodenum
quantitative CEUS
repeatability
Issue Date: Sep-2017
Publisher: 公益社団法人 日本獣医学会
Journal Title: Journal of veterinary medical science
Volume: 79
Issue: 9
Start Page: 1585
End Page: 1590
Publisher DOI: 10.1292/jvms.17-0174
Abstract: Contrast-enhanced ultrasonography (CEUS) with microbubbles as a contrast agent allows the visualization and quantification of tissue perfusion. The assessment of canine intestinal perfusion by quantitative CEUS may provide valuable information for diagnosing and monitoring chronic intestinal disorders. This study aimed to assess the repeatability (intraday variability) and reproducibility (interday variability) of quantitative duodenal CEUS in healthy dogs. Six healthy beagles underwent CEUS three times within one day (4-hr intervals) and on two different days (1-week interval). All dogs were sedated with a combination of butorphanol (0.2 mg/kg) and midazolam (0.1 mg/kg) prior to CEUS. The contrast agent (Sonazoid (R)) was administered using the intravenous bolus method (0.01 ml/kg) for imaging of the duodenum. Time-intensity curves (TIC) were created by drawing multiple regions of interest (ROIs) in the duodenal mucosa, and perfusion parameters, including the time-to-peak (TTP), peak intensity (PI), area under the curve (AUC), and wash-in and wash-out rates (WiR and WoR, respectively), were generated. Intraday and interday coefficients of variation (CVs) for TTP, PI, AUC, WiR and WoR were < 25% (range, 2.27-23.41%), which indicated that CEUS was feasible for assessing duodenal perfusion in healthy sedated dogs. A further study of CEUS in dogs with chronic intestinal disorders is necessary to evaluate its clinical applicability.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/70873
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 滝口 満喜

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