| Title: | Repeatability and reproducibility of quantitative contrast-enhanced ultrasonography for assessing duodenal perfusion in healthy dogs |
| Authors: | Nisa, Khoirun Browse this author |
| Lim, Sue Yee Browse this author |
| Shinohara, Masayoshi Browse this author |
| Nagata, Noriyuki Browse this author |
| Sasaoka, Kazuyoshi Browse this author |
| Dermlim, Angkhana Browse this author |
| Leela-Arporn, Rommaneeya Browse this author |
| Morita, Tomoya Browse this author |
| Yokoyama, Nozomu Browse this author |
| Osuga, Tatsuyuki Browse this author |
| Sasaki, Noboru Browse this author |
| Morishita, Keitaro Browse this author →KAKEN DB |
| Nakamura, Kensuke Browse this author |
| Ohta, Hiroshi Browse this author →KAKEN DB |
| Takiguchi, Mitsuyoshi Browse this author →KAKEN DB |
| Keywords: | canine |
| duodenum |
| quantitative CEUS |
| repeatability |
| Issue Date: | Sep-2017 |
| Publisher: | 公益社団法人 日本獣医学会 |
| Journal Title: | Journal of veterinary medical science |
| Volume: | 79 |
| Issue: | 9 |
| Start Page: | 1585 |
| End Page: | 1590 |
| Publisher DOI: | 10.1292/jvms.17-0174 |
| Abstract: | Contrast-enhanced ultrasonography (CEUS) with microbubbles as a contrast agent allows the visualization and quantification of tissue perfusion. The assessment of canine intestinal perfusion by quantitative CEUS may provide valuable information for diagnosing and monitoring chronic intestinal disorders. This study aimed to assess the repeatability (intraday variability) and reproducibility (interday variability) of quantitative duodenal CEUS in healthy dogs. Six healthy beagles underwent CEUS three times within one day (4-hr intervals) and on two different days (1-week interval). All dogs were sedated with a combination of butorphanol (0.2 mg/kg) and midazolam (0.1 mg/kg) prior to CEUS. The contrast agent (Sonazoid (R)) was administered using the intravenous bolus method (0.01 ml/kg) for imaging of the duodenum. Time-intensity curves (TIC) were created by drawing multiple regions of interest (ROIs) in the duodenal mucosa, and perfusion parameters, including the time-to-peak (TTP), peak intensity (PI), area under the curve (AUC), and wash-in and wash-out rates (WiR and WoR, respectively), were generated. Intraday and interday coefficients of variation (CVs) for TTP, PI, AUC, WiR and WoR were < 25% (range, 2.27-23.41%), which indicated that CEUS was feasible for assessing duodenal perfusion in healthy sedated dogs. A further study of CEUS in dogs with chronic intestinal disorders is necessary to evaluate its clinical applicability. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70873 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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