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Serum placental growth factor and soluble fms-like tyrosine kinase 1 at mid-gestation in healthy women : Association with small-for-gestational-age neonates

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Title: Serum placental growth factor and soluble fms-like tyrosine kinase 1 at mid-gestation in healthy women : Association with small-for-gestational-age neonates
Other Titles: Serum placental growth factor and soluble fms-like tyrosine kinase 1 at mid-gestation in healthy women : association with small for gestational age neonates
Placental growth factor and SGA
Authors: Furuta, Itsuko Browse this author →KAKEN DB
Umazume, Takeshi Browse this author →KAKEN DB
Kojima, Takashi Browse this author
Chiba, Kentaro Browse this author
Nakagawa, Kinuko Browse this author
Hosokawa, Ami Browse this author
Ishikawa, Satoshi Browse this author
Yamada, Takahiro Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: biomarker
fetal growth restriction
placental growth factor
small for gestational age
Issue Date: Jul-2017
Publisher: John Wiley & Sons
Journal Title: Journal of Obstetrics and Gynaecology Research
Volume: 43
Issue: 7
Start Page: 1152
End Page: 1158
Publisher DOI: 10.1111/jog.13340
PMID: 28422347
Abstract: Aims: This study was performed to determine the associations between serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels at mid-gestation with the risk of small for gestational age (SGA) neonates born at gestational week (GW) ≥ 36 in healthy women. Methods: PlGF and sFlt-1 concentrations were determined at GW 24-27 in 183 women with births at GW ≥ 36, but without gestational diabetes mellitus and hypertension. Results: Thirteen (7.1%) SGA neonates were born. Median (range) GW at blood sampling was similar between women with and without SGA (25 [24-25] and 24 [24-27], respectively, P = 0.671). Pre-pregnancy body mass index (BMI) and PlGF levels were significantly lower in women with than without SGA, while sFlt-1 levels and sFlt-1:PlGF ratio (sFlt-1/PlGF) did not differ significantly between the two groups. PlGF and sFlt-1/PlGF, but not BMI or sFlt-1, showed significant correlations with birthweight z-score; the correlation was positive for PlGF and negative for sFlt-1/PlGF. Women with PlGF level < 10th percentile and those with sFlt-1/PlGF level > 90th percentile showed significantly increased risk of SGA compared to those with respective counterpart characteristics; relative risk was 3.8 (95% CI, 1.3 - 11.3; 21% [4/19] vs. 5.5% [9/164]) for PlGF and 7.9 (3.0 - 20.8, 33.3% [6/18] vs. 4.2% [7/165]) for sFlt-1/PlGF. Conclusions: Maternal PlGF and sFlt-1/PlGF determined during GW 24-27 were associated with the risk of SGA born at GW ≥ 36, even in women with uncomplicated pregnancies.
Rights: This is the peer reviewed version of the following article: Itsuko Furuta, Takeshi Umazume, Takashi Kojima, Kentaro Chiba, Kinuko Nakagawa, Ami Hosokawa, Satoshi Ishikawa, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami, Serum placental growth factor and soluble fms-like tyrosine kinase 1 at mid-gestation in healthy women: Association with small-for-gestational-age neonates, The Journal of Obstetrics and Gynaecology Research, Volume43, Issue7, 2017, pp.1152-1158, which has been published in final form at https://doi.org/10.1111/jog.13340. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/70897
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 水上 尚典

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