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Hokkaido University Collection of Scholarly and Academic Papers >
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Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases
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| Title: | Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases |
| Other Titles: | Effects of age and glucose on lactate in CSF |
| Authors: | Nakano, Fumihito Browse this author | | Sakushima, Ken Browse this author | | Umeki, Reona Browse this author | | Yabe, Ichiro Browse this author →KAKEN DB | | Endoh, Akira Browse this author | | Sasaki, Hidenao Browse this author →KAKEN DB |
| Keywords: | Cerebrospinal fluid | | Lactate | | Glucose | | Age | | Neurodegenerative disease |
| Issue Date: | 15-Jul-2017 |
| Publisher: | Elsevier |
| Journal Title: | Journal of the neurological sciences |
| Volume: | 378 |
| Start Page: | 45 |
| End Page: | 48 |
| Publisher DOI: | 10.1016/j.jns.2017.04.033 |
| PMID: | 28566176 |
| Abstract: | Despite recent studies examining the association between neurodegenerative diseases and mitochondrial dysfunction, there are not sufficient data on factors that influence cerebrospinal fluid (CSF) lactate levels. Thus, we investigated factors that affect CSF lactate levels in neurodegenerative diseases. We extracted laboratory findings, including CSF lactate, glucose, and protein levels, and demographic and background information, including age and gender, from the electronic medical records of patients with neurodegenerative diseases in order to explore factors that have an impact CSF lactate levels. These patients had been admitted to our department and underwent a CSF examination between April 2007 and March 2015. Data from 83 patients (average age 64.5 years; 45 males and 38 females) were analyzed. The patients' diagnoses included amyotrophic lateral sclerosis, multiple system atrophy, spinocerebellar degeneration, corticobasal syndrome, Parkinson's disease, and Huntington's disease. CSF lactate levels were higher in patients with a neurodegenerative disease who were aged 65 years and older relative to those who were aged under 65 years (p < 0.05), and CSF lactate and glucose levels showed a moderate positive correlation (r = 0.487). Age and CSF glucose levels influenced CSF lactate levels even after adjusting for gender, age, CSF protein levels, and CSF glucose levels. When investigating CSF lactate levels in neurodegenerative diseases, it is necessary to consider patients' age and CSF glucose levels. |
| Rights: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/70975 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐々木 秀直
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