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Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases

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Title: Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases
Other Titles: Effects of age and glucose on lactate in CSF
Authors: Nakano, Fumihito Browse this author
Sakushima, Ken Browse this author
Umeki, Reona Browse this author
Yabe, Ichiro Browse this author →KAKEN DB
Endoh, Akira Browse this author
Sasaki, Hidenao Browse this author →KAKEN DB
Keywords: Cerebrospinal fluid
Neurodegenerative disease
Issue Date: 15-Jul-2017
Publisher: Elsevier
Journal Title: Journal of the neurological sciences
Volume: 378
Start Page: 45
End Page: 48
Publisher DOI: 10.1016/j.jns.2017.04.033
PMID: 28566176
Abstract: Despite recent studies examining the association between neurodegenerative diseases and mitochondrial dysfunction, there are not sufficient data on factors that influence cerebrospinal fluid (CSF) lactate levels. Thus, we investigated factors that affect CSF lactate levels in neurodegenerative diseases. We extracted laboratory findings, including CSF lactate, glucose, and protein levels, and demographic and background information, including age and gender, from the electronic medical records of patients with neurodegenerative diseases in order to explore factors that have an impact CSF lactate levels. These patients had been admitted to our department and underwent a CSF examination between April 2007 and March 2015. Data from 83 patients (average age 64.5 years; 45 males and 38 females) were analyzed. The patients' diagnoses included amyotrophic lateral sclerosis, multiple system atrophy, spinocerebellar degeneration, corticobasal syndrome, Parkinson's disease, and Huntington's disease. CSF lactate levels were higher in patients with a neurodegenerative disease who were aged 65 years and older relative to those who were aged under 65 years (p < 0.05), and CSF lactate and glucose levels showed a moderate positive correlation (r = 0.487). Age and CSF glucose levels influenced CSF lactate levels even after adjusting for gender, age, CSF protein levels, and CSF glucose levels. When investigating CSF lactate levels in neurodegenerative diseases, it is necessary to consider patients' age and CSF glucose levels.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 秀直

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