|
Hokkaido University Collection of Scholarly and Academic Papers >
Institute for Genetic Medicine >
Peer-reviewed Journal Articles, etc >
Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues |
| Authors: | Sasaki, Ayana Browse this author | | Nagatake, Takahiro Browse this author | | Egami, Riku Browse this author | | Gu, Guoqiang Browse this author | | Takigawa, Ichigaku Browse this author →KAKEN DB | | Ikeda, Wataru Browse this author | | Nakatani, Tomoya Browse this author | | Kunisawa, Jun Browse this author | | Fujita, Yasuyuki Browse this author →KAKEN DB |
| Issue Date: | 24-Apr-2018 |
| Publisher: | Cell Press |
| Journal Title: | Cell Reports |
| Volume: | 23 |
| Issue: | 4 |
| Start Page: | 974 |
| End Page: | 982 |
| Publisher DOI: | 10.1016/j.celrep.2018.03.104 |
| Abstract: | Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelial tissues via cell competition with the surrounding normal epithelial cells. This cancer preventive phenomenon is termed epithelial defense against cancer (EDAC). However, it remains largely unknown whether and how EDAC is diminished during carcino-genesis. In this study, using a cell competition mouse model, we show that high-fat diet (HFD) feeding substantially attenuates the frequency of apical elimination of RasV12-transformed cells from intestinal and pancreatic epithelia. This process involves both lipid metabolism and chronic inflammation. Furthermore, aspirin treatment significantly facilitates eradication of transformed cells from the epithelial tissues in HFD-fed mice. Thus, our work demonstrates that obesity can profoundly influence competitive interaction between normal and transformed cells, providing insights into cell competition and cancer preventive medicine. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/70992 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 藤田 恭之
|
