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Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy
Title: | Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy |
Other Titles: | Intestinal metastasis in melanoma |
Authors: | Miyazawa, Hajime Browse this author | Yanagi, Teruki Browse this author →KAKEN DB | Yamaguchi, Yasuyuki Browse this author | Imafuku, Keisuke Browse this author | Kitamura, Shinya Browse this author | Hata, Hiroo Browse this author →KAKEN DB | Uehara, Jiro Browse this author | Ichikawa, Nobuki Browse this author →KAKEN DB | Ohno, Yosuke Browse this author | Yoshida, Tadashi Browse this author →KAKEN DB | Homma, Shigenori Browse this author →KAKEN DB | Kawamura, Hideki Browse this author →KAKEN DB | Taketomi, Akinobu Browse this author →KAKEN DB | Shimizu, Hiroshi Browse this author →KAKEN DB |
Keywords: | fecal occult blood test | intestinal metastasis | malignant melanoma | nivolumab | weight loss |
Issue Date: | Aug-2017 |
Publisher: | John Wiley & Sons |
Journal Title: | Journal of dermatology |
Volume: | 44 |
Issue: | 8 |
Start Page: | 959 |
End Page: | 962 |
Publisher DOI: | 10.1111/1346-8138.13825 |
PMID: | 28295515 |
Abstract: | We report two cases of melanomas in patients who developed intestinal metastasis despite other metastatic sites responding to nivolumab and despite the patients having favorable findings such as vitiligo and normal lactate dehydrogenase. The first case is an 85-year-old man who had been administrated nivolumab for lung/cutaneous metastases. After 22 courses of nivolumab therapy, fever and anorexia had appeared and his bodyweight had decreased. An intussusception on the ileocecal valve was revealed by computed tomography, and emergency surgery revealed metastatic lesions on the colon. The second case is an 87-year-old woman treated with nivolumab for lymph node metastases. After 10 courses, laboratory tests had revealed anemia and positive fecal occult blood. Her bodyweight had decreased. Capsule endoscopy showed scattered tumors and clots, indicating metastases of melanoma. The frequency of symptomatic intestinal metastasis of melanoma is very low. Further, intestinal metastasis of melanoma is difficult to detect through routine examinations. Our cases suggest that fecal occult blood test and decreased bodyweight are indications of intestinal metastases. |
Rights: | This is the peer reviewed version of the following article: Miyazawa, H., Yanagi, T., Yamaguchi, Y., Imafuku, K., Kitamura, S., Hata, H., Uehara, J., Ichikawa, N., Ohno, Y., Yoshida, T., Homma, S., Kawamura, H., Taketomi, A. and Shimizu, H. (2017), Two cases of melanomas paradoxically metastasizing to the intestinal tract during nivolumab therapy. J Dermatol, 44: 959-962., which has been published in final form at https://doi.org/10.1111/1346-8138.13825. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/71133 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 柳 輝希
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