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Passive smoking and mortality from aortic dissection or aneurysm

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Title: Passive smoking and mortality from aortic dissection or aneurysm
Authors: Kihara, Tomomi Browse this author
Yamagishi, Kazumasa Browse this author
Iso, Hiroyasu Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Aorta
Cardiovascular disease
Environmental tobacco smoke
Secondhand smoke
Issue Date: Aug-2017
Publisher: Elsevier
Journal Title: Atherosclerosis
Volume: 263
Start Page: 145
End Page: 150
Publisher DOI: 10.1016/j.atherosclerosis.2017.06.022
PMID: 28645070
Abstract: Background and aims: Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm. Methods: The Japan Collaborative Cohort (JACC) Study is a prospective community-based cohort study begun in 1988-90 and followed up to the end of 2009. We examined 48,677 individuals (mean age, 56 years; women, 46%) without history of stroke, coronary heart disease, or cancer, who provided valid responses to a lifestyle questionnaire including questions on active and passive smoking. We used 3 categories (passive smoking out of home, passive smoking at home, and passive smoking out of or at home combined) to divide never-smokers into 3 exposure groups: low, intermediate, and high exposures, respectively. The endpoint was underlying cause of death from aortic dissection or aneurysm. Results: During the median 19-year follow-up of 48,677 study participants, 66 died of aortic dissection, and 75 of aortic aneurysm. Multivariable hazard ratios (95% confidence intervals) for the high passive-smoking group as compared with the low passive-smoking group were 2.45 (1.02-5.88) out of home, 1.82 (0.84-3.96) at home, and 2.35 (1.09-5.09) out of or at home combined. The corresponding hazard ratios for current smokers as compared with the low passive-smoking group were 3.97 (2.14-7.39), 3.41 (1.84-6.32) and 4.09 (1.99-8.39), respectively. Conclusions: Out-of-home passive smoking and out-of-or at-home combined passive smoking were associated with increased mortality from aortic dissection or aneurysm.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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