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Study on the Effect of Obesity on Epithelial Defense against Cancer
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| Title: | Study on the Effect of Obesity on Epithelial Defense against Cancer |
| Other Titles: | 上皮細胞に備わる発がん防御機構[EDAC]における肥満の影響に関する研究 | | Study on the Effect of Obesity on Epithelial Defense against Cancer (EDAC) |
| Authors: | 佐々木, 彩名1 Browse this author |
| Authors(alt): | Sasaki, Ayana1 |
| Issue Date: | 29-Jun-2018 |
| Publisher: | Hokkaido University |
| Abstract: | Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelial tissues via cell competition with the surrounding normal epithelial cells. This cancer preventive phenomenon is termed Epithelial Defense Against Cancer (EDAC). However, it remains largely unknown whether and how EDAC is diminished during carcinogenesis. In this study, using a newly established cell competition mouse model, I show that high-hat diet (HFD)-feeding substantially attenuates the frequency of apical elimination of RasV12-transformed cells from intestinal and pancreatic epithelia, leading to the formation of precancerous tumors. This process involves both lipid metabolism and chronic inflammation. Furthermore, aspirin treatment significantly facilitates eradication of transformed cells from the epithelial tissues in HFD-fed mice. This is the first report demonstrating that obesity can profoundly influence competitive interaction between normal and transformed cells, providing new insights into cell competition and cancer preventive medicine. |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第13277号 |
| Degree Level: | 博士 |
| Degree Discipline: | 理学 |
| Examination Committee Members: | (主査) 教授 村上 洋太, 教授 髙木 睦, 教授 髙岡 晃教, 教授 藤田 恭之 |
| Degree Affiliation: | 総合化学院（総合化学専攻） |
| Type: | theses (doctoral) |
| URI: | http://hdl.handle.net/2115/71327 |
| Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 総合化学院(Graduate School of Chemical Sciences and Engineering)
学位論文 (Theses) > 博士 （理学）
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