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Volume 66 Number 3 >

Cattle with a low bovine leukemia virus proviral load are rarely an infectious source

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Title: Cattle with a low bovine leukemia virus proviral load are rarely an infectious source
Authors: Mekata, Hirohisa Browse this author
Yamamoto, Mari Browse this author
Hayashi, Takumi Browse this author
Kirino, Yumi Browse this author
Sekiguchi, Satoshi Browse this author
Konnai, Satoru Browse this author →KAKEN DB
Horii, Yoichiro Browse this author
Norimine, Junzo Browse this author
Keywords: BLV
infectious source
proviral load
virus transmission
Issue Date: Aug-2018
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 66
Issue: 3
Start Page: 157
End Page: 163
Abstract: Bovine leukemia virus (BLV) is an etiological agent of fatal B-cell leukemia and malignant lymphoma in cattle. Cattle with higher BLV proviral loads represent a higher risk of both horizontal and vertical transmission. Therefore, quantifying the proviral load of BLV is important in identifying major infectious sources and protecting BLV-free cattle from exposure to infected cattle. In this study, we confirmed that cattle with very low BLV proviral loads did not transmit the virus to virus-free cattle under conventional conditions. We observed a total of 7 tests in which a BLV-infected bull was allowed to cohabit with 57 to 92 BLV-free cattle for 12 or 22 months. We then evaluated the frequency of viral transmission. A BLV-infected bull with a “very low proviral load” (i.e., fewer than 100 proviral copies/50 ng of genomic DNA) did not transmit the virus to any virus-free cattle in 2 out of 2 tests. However, a BLV-infected bull with a “low proviral load” (i.e., 100 to 500 copies/50 ng) transmitted the virus to a total of 3 virus-free cattle in 2 out of 5 tests. These results suggest that BLV-infected cattle with “very low proviral loads” do not transmit the virus under conventional conditions, while cattle with “low proviral loads” can transmit the virus, although at low rates. We believe that the results of this study will promote the construction of effective measures to prevent BLV infection and control the spread of BLV.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 66 Number 3

Submitter: 獣医学部図書室

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