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Volume 66 Number 3 >

Identification of immuno-inhibitory molecules in Mongolian native cattle and yak

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Title: Identification of immuno-inhibitory molecules in Mongolian native cattle and yak
Authors: Ochirkhuu, Nyamsuren Browse this author
Konnai, Satoru Browse this author →KAKEN DB
Odbileg, Raadan Browse this author
Ganbaatar, Otgontuya Browse this author
Okagawa, Tomohiro Browse this author
Maekawa, Naoya Browse this author
Murata, Shiro Browse this author →KAKEN DB
Ohashi, Kazuhiko Browse this author →KAKEN DB
Keywords: Immuno-inhibitory molecule
Mongolian native cattle
Mongolian yak
Issue Date: Aug-2018
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 66
Issue: 3
Start Page: 177
End Page: 192
Abstract: The immuno-inhibitory molecules PD-1, PD-L1, TIM-3, GAL-9, LAG-3, and CTLA-4 from blood samples of Mongolian native cattle and yak were characterized through cloning and sequencing. As these molecules are involved in cell-mediated immune responses, identifying the differences in their reactions against the pathogens found in bovine species may be beneficial. The amino acid sequences of these molecules were predicted for the purpose of characterizing their functional domains, such as the signal peptide, extracellular domain, transmembrane region, and intracellular domain. Amino acid alignment showed that the sequences of these immuno-inhibitory molecules from Mongolian native cattle and yak were highly homologous to those from other bovine species. As a preliminary application of the genetic information, we conducted expression analysis of PD-L1 in bovine viral diarrhea virus (BVDV)-infected yak by using real-time polymerase chain reaction, and PD-L1 mRNA expression in peripheral blood mononuclear cells derived from BVDV-infected yak was significantly upregulated compared to that of uninfected-yak. Further studies are necessary to assess whether these molecules play roles in disease progression during chronic infection of Mongolian native cattle and yak.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 66 Number 3

Submitter: 獣医学部図書室

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