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The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus

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Title: The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus
Authors: Matsuno, Keita Browse this author →KAKEN DB
Kajihara, Masahiro Browse this author
Nakao, Ryo Browse this author →KAKEN DB
Nao, Naganori Browse this author
Mori-Kajihara, Akina Browse this author
Muramatsu, Mieko Browse this author
Qiu, Yongjin Browse this author
Torii, Shiho Browse this author
Igarashi, Manabu Browse this author →KAKEN DB
Kasajima, Nodoka Browse this author
Mizuma, Keita Browse this author
Yoshii, Kentaro Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Sugimoto, Chihiro Browse this author →KAKEN DB
Takada, Ayato Browse this author →KAKEN DB
Ebihara, Hideki Browse this author
Keywords: ancestral state
phylogenetic analysis
tick-borne phlebovirus
Issue Date: 13-Jun-2018
Publisher: American Society for Microbiology
Journal Title: mSphere
Volume: 3
Issue: 3
Start Page: e00239-18
Publisher DOI: 10.1128/mSphere.00239-18
Abstract: The recent emergence of novel tick-borne RNA viruses has complicated the epidemiological landscape of tick-borne infectious diseases, posing a significant challenge to public health systems that seek to counteract tick-borne diseases. The identification of two novel tick-borne phleboviruses (TBPVs), severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV), as causative agents of severe illness in humans has accelerated the investigation and discoveries of novel TBPVs. In the present study, we isolated a novel TBPV designated Mukawa virus (MKWV) from host-questing Ixodes persulcatus females captured in Japan. Genetic characterization revealed that MKWV is a member of the genus Phlebovirus in the family Phenuiviridae. Interestingly, MKWV is genetically distinct from other known TBPVs and shares a most recent common ancestor with mosquito/sandfly-borne (insect-borne) phleboviruses. Despite its genetic similarity to insect-borne phleboviruses, the molecular footprints of its viral proteins and its biological characteristics define MKWV as a tick-borne virus that can be transmitted to mammals. A phylogenetic ancestral-state reconstruction for arthropod vectors of phleboviruses including MKWV based on viral L segment sequences indicated that ticks likely harbored ancestral phleboviruses that evolved into both the tick-borne and MKWV/insect-borne phlebovirus lineages. Overall, our findings suggest that most of the phlebovirus evolution has occurred in hard ticks to generate divergent viruses, which may provide a seminal foundation for understanding the mechanisms underlying the evolution and emergence of pathogenic phleboviruses, such as Rift Valley fever virus and SFTSV/HRTV.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松野 啓太

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