Title: | The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus |
Authors: | Matsuno, Keita Browse this author →KAKEN DB |
Kajihara, Masahiro Browse this author |
Nakao, Ryo Browse this author →KAKEN DB |
Nao, Naganori Browse this author |
Mori-Kajihara, Akina Browse this author |
Muramatsu, Mieko Browse this author |
Qiu, Yongjin Browse this author |
Torii, Shiho Browse this author |
Igarashi, Manabu Browse this author →KAKEN DB |
Kasajima, Nodoka Browse this author |
Mizuma, Keita Browse this author |
Yoshii, Kentaro Browse this author →KAKEN DB |
Sawa, Hirofumi Browse this author →KAKEN DB |
Sugimoto, Chihiro Browse this author →KAKEN DB |
Takada, Ayato Browse this author →KAKEN DB |
Ebihara, Hideki Browse this author |
Keywords: | ancestral state |
evolution |
phylogenetic analysis |
tick-borne phlebovirus |
Issue Date: | 13-Jun-2018 |
Publisher: | American Society for Microbiology |
Journal Title: | mSphere |
Volume: | 3 |
Issue: | 3 |
Start Page: | e00239-18 |
Publisher DOI: | 10.1128/mSphere.00239-18 |
Abstract: | The recent emergence of novel tick-borne RNA viruses has complicated the epidemiological landscape of tick-borne infectious diseases, posing a significant challenge to public health systems that seek to counteract tick-borne diseases. The identification of two novel tick-borne phleboviruses (TBPVs), severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV), as causative agents of severe illness in humans has accelerated the investigation and discoveries of novel TBPVs. In the present study, we isolated a novel TBPV designated Mukawa virus (MKWV) from host-questing Ixodes persulcatus females captured in Japan. Genetic characterization revealed that MKWV is a member of the genus Phlebovirus in the family Phenuiviridae. Interestingly, MKWV is genetically distinct from other known TBPVs and shares a most recent common ancestor with mosquito/sandfly-borne (insect-borne) phleboviruses. Despite its genetic similarity to insect-borne phleboviruses, the molecular footprints of its viral proteins and its biological characteristics define MKWV as a tick-borne virus that can be transmitted to mammals. A phylogenetic ancestral-state reconstruction for arthropod vectors of phleboviruses including MKWV based on viral L segment sequences indicated that ticks likely harbored ancestral phleboviruses that evolved into both the tick-borne and MKWV/insect-borne phlebovirus lineages. Overall, our findings suggest that most of the phlebovirus evolution has occurred in hard ticks to generate divergent viruses, which may provide a seminal foundation for understanding the mechanisms underlying the evolution and emergence of pathogenic phleboviruses, such as Rift Valley fever virus and SFTSV/HRTV. |
Rights: | https://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/71358 |
Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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